POLR2A and XRCC5

Number of citations of the paper that reports this interaction (PMID 12391174)
24

Data Source:
HPRD (in vitro, in vivo)

		POLR2A	XRCC5
Gene Name		polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
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Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Metal Ion Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, RNA-templated DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process Positive Regulation Of RNA Splicing PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Transcription, DNA-templated Brain Development Cell Proliferation Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		100 interactors: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTD CTDP1 CTDSP1 CTDSP2 DHX9 ELL ERCC5 ERCC6 ERG FCP1 FUS GRB2 GTF2B GTF2E1 GTF2H4 HIST1H1C HNRNPF HNRNPU HTATSF1 ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYC NEDD4 NELFA NONO NR0B2 PCIF1 PHF8 PIN1 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2K POLR2L PPIG PPP1CA PQBP1 PRPF19 RECQL5 SAFB SETD2 SMN1 SMN2 SMURF1 SND1 SUB1 SUPT5H TAF10 TBP TCEA1 TCEB3 TCERG1 TRAK1 TRAM2 U2AF2 UBC UBE2L3 UPF1 WAC WWP2 XAB2 XRCC5 ZNF74	47 interactors: APEX1 APLF AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RUNX2 SGOL1 SUMO1 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP2B TYK2 VAV1 WRN XRCC6
Entrez ID		5430	7520
HPRD ID		08916	08935
Ensembl ID		ENSG00000181222	ENSG00000079246
Uniprot IDs		P24928	P13010
PDB IDs		2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P	1JEQ 1JEY 1Q2Z 1RW2 3RZ9
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Viral Transcription Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Viral Process MRNA Processing Cellular Macromolecule Biosynthetic Process RNA Processing MRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation RNA Splicing Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome Cellular Metabolic Process RNA Splicing, Via Transesterification Reactions 7-methylguanosine MRNA Capping Regulation Of RNA Biosynthetic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus DNA Repair Nucleotide-excision Repair Regulation Of Metabolic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Termination DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter	DNA Metabolic Process Telomere Maintenance DNA Replication DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Double-strand Break Repair Regulation Of Nitrogen Compound Metabolic Process Response To Stress Chromosome Organization Biosynthetic Process DNA-dependent DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Mitotic Recombination Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process DNA Strand Elongation Base-excision Repair Transcription From RNA Polymerase II Promoter Cell Cycle Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?