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POLR2A and XRCC5
Number of citations of the paper that reports this interaction (PubMedID
12391174
)
76
Data Source:
HPRD
(in vitro, in vivo)
POLR2A
XRCC5
Description
RNA polymerase II subunit A
X-ray repair cross complementing 5
Image
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Chromosome
Nucleolus
Cytoplasm
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Molecular Function
Magnesium Ion Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
DNA-directed RNA Polymerase Activity
RNA-directed RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Nucleotidyltransferase Activity
Hydrolase Activity
Kinase Binding
Ubiquitin Protein Ligase Binding
5'-3' RNA Polymerase Activity
Metal Ion Binding
Microfibril Binding
Promoter-specific Chromatin Binding
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Biological Process
RNA-templated Transcription
DNA-templated Transcription
DNA-templated Transcription Termination
Regulation Of DNA-templated Transcription
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Gene Expression
Positive Regulation Of RNA Splicing
MRNA Transcription By RNA Polymerase II
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Negative Regulation Of Macromolecule Biosynthetic Process
Neurogenesis
Regulation Of Telomere Maintenance
Small-subunit Processome Assembly
Ribosome Biogenesis
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Hematopoietic Stem Cell Proliferation
Cellular Response To Gamma Radiation
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Diseases
GWAS
Atrial fibrillation (
29892015
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
32888494
)
Myopia (
27182965
)
Parkinson's disease progression (cognitive) (
33958783
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
103 interacting genes:
ABL1
ACTB
ACTL6A
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
EIF4ENIF1
ELL
ERCC5
ERCC6
ERCC8
ERG
ESR1
FUS
GRB2
GTF2B
GTF2H4
H1-2
HNRNPF
HTATSF1
IFTAP
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2L
PPIG
PPP1CA
PPP2CA
PQBP1
PRMT5
PRPF19
PTEN
RNF10
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUMO2
SUPT5H
TAF10
TCEA1
TCERG1
TDRD3
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
XAB2
XRCC5
ZC3H4
ZNF74
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DEAF1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
Entrez ID
5430
7520
HPRD ID
08916
08935
Ensembl ID
ENSG00000181222
ENSG00000079246
Uniprot IDs
A0AAG2TJB2
P24928
P13010
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6IC8
6IC9
6O9L
6Q5Y
6XKB
6XRE
7EGB
7EGC
7LBM
7YCX
7Z1K
7Z42
8PM0
8PNP
8PNQ
8R3K
8R3L
8R60
8R65
9B9L
9EHZ
9EI1
9EI2
9EI3
9EI4
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
7AXZ
7K0Y
7K17
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7SUD
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Nucleic Acid Metabolic Process
Nucleus
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
MRNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-templated Transcription Elongation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of DNA Metabolic Process
DNA Repair
Regulation Of Cell Cycle
Regulation Of DNA Repair
DNA Metabolic Process
Regulation Of DNA-templated Transcription Elongation
Positive Regulation Of Transcription Elongation By RNA Polymerase II
MRNA Processing
RNA Polymerase II, Core Complex
DNA Damage Response
Transcription Elongation By RNA Polymerase II
Chromatin Binding
Regulation Of Cell Cycle Process
RNA Polymerase Binding
Regulation Of Transcription Elongation By RNA Polymerase II
Chromatin Organization
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Response To Stress
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Positive Regulation Of DNA Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Telomere Maintenance
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Binding
Response To Gamma Radiation
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Macromolecule Biosynthetic Process
Telomere Organization
Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
DNA Replication
Regulation Of Double-strand Break Repair
Chromatin Binding
Nucleobase-containing Compound Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromosome Organization
Positive Regulation Of DNA-templated Transcription
DNA Recombination
Negative Regulation Of DNA Metabolic Process
DNA Strand Elongation
Regulation Of Gene Expression
Recombinational Repair
Response To Ionizing Radiation
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Tagcloud (Intersection)
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