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POLR2A and GTF2H4
Number of citations of the paper that reports this interaction (PMID
9159119
)
77
Data Source:
BioGRID
(pull down)
POLR2A
GTF2H4
Gene Name
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
general transcription factor IIH, polypeptide 4, 52kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Prp19 Complex
Nucleus
Nucleoplasm
DNA-directed RNA Polymerase II, Core Complex
Nucleolus
Core TFIIH Complex
Nucleoplasm
Holo TFIIH Complex
Molecular Function
RNA Polymerase II Activity
DNA Binding
DNA-directed RNA Polymerase Activity
RNA-directed RNA Polymerase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Poly(A) RNA Binding
Metal Ion Binding
Sequence-specific DNA Binding Transcription Factor Activity
ATP-dependent DNA Helicase Activity
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II Carboxy-terminal Domain Kinase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Transcription, RNA-templated
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
RNA Splicing
Gene Expression
Viral Process
Positive Regulation Of RNA Splicing
PiRNA Metabolic Process
Somatic Stem Cell Maintenance
Positive Regulation Of Viral Transcription
Nucleotide-excision Repair, DNA Damage Removal
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Gene Expression
Viral Process
DNA Duplex Unwinding
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Pathways
RNA Polymerase II Promoter Escape
mRNA Splicing
Formation of HIV-1 elongation complex containing HIV-1 Tat
PIWI-interacting RNA (piRNA) biogenesis
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription
Abortive elongation of HIV-1 transcript in the absence of Tat
HIV Infection
Regulatory RNA pathways
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
Influenza Life Cycle
HIV elongation arrest and recovery
HIV Life Cycle
HIV Transcription Initiation
Influenza Viral RNA Transcription and Replication
RNA Pol II CTD phosphorylation and interaction with CE
Transcriptional regulation of pluripotent stem cells
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation by small RNAs
Processing of Capped Intron-Containing Pre-mRNA
mRNA Capping
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
MicroRNA (miRNA) biogenesis
Influenza Infection
Pausing and recovery of Tat-mediated HIV elongation
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
RNA Polymerase II Transcription Initiation And Promoter Clearance
Pausing and recovery of HIV elongation
Formation of HIV elongation complex in the absence of HIV Tat
Transcription-coupled NER (TC-NER)
Viral Messenger RNA Synthesis
Formation of the HIV-1 Early Elongation Complex
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
NoRC negatively regulates rRNA expression
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
Dual incision reaction in GG-NER
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
Global Genomic NER (GG-NER)
RNA Polymerase II Transcription Initiation And Promoter Clearance
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of incision complex in GG-NER
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Ulcerative colitis (
20848476
)
Protein-Protein Interactions
100 interactors:
ABL1
ACTB
ACTL6A
ATM
BARD1
BRCA1
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK7
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTD
CTDP1
CTDSP1
CTDSP2
DHX9
ELL
ERCC5
ERCC6
ERG
FCP1
FUS
GRB2
GTF2B
GTF2E1
GTF2H4
HIST1H1C
HNRNPF
HNRNPU
HTATSF1
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYC
NEDD4
NELFA
NONO
NR0B2
PCIF1
PHF8
PIN1
POLR2B
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2I
POLR2K
POLR2L
PPIG
PPP1CA
PQBP1
PRPF19
RECQL5
SAFB
SETD2
SMN1
SMN2
SMURF1
SND1
SUB1
SUPT5H
TAF10
TBP
TCEA1
TCEB3
TCERG1
TRAK1
TRAM2
U2AF2
UBC
UBE2L3
UPF1
WAC
WWP2
XAB2
XRCC5
ZNF74
10 interactors:
ERCC3
ERCC5
GTF2B
GTF2E1
GTF2F1
GTF2H3
POLR2A
TBP
TP53
XBP1P1
Entrez ID
5430
2968
HPRD ID
08916
03456
Ensembl ID
ENSG00000181222
ENSG00000213780
Uniprot IDs
P24928
Q92759
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
Enriched GO Terms of Interacting Partners
?
Transcription Elongation From RNA Polymerase II Promoter
DNA-templated Transcription, Elongation
RNA Metabolic Process
Positive Regulation Of Viral Transcription
Gene Expression
Nucleobase-containing Compound Metabolic Process
Transcription, DNA-templated
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Viral Process
MRNA Processing
Cellular Macromolecule Biosynthetic Process
RNA Processing
MRNA Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Gene Expression
Transcription-coupled Nucleotide-excision Repair
Regulation Of RNA Metabolic Process
DNA-templated Transcription, Initiation
RNA Splicing
Biosynthetic Process
Regulation Of Viral Process
Regulation Of Nitrogen Compound Metabolic Process
MRNA Splicing, Via Spliceosome
Cellular Metabolic Process
RNA Splicing, Via Transesterification Reactions
7-methylguanosine MRNA Capping
Regulation Of RNA Biosynthetic Process
7-methylguanosine RNA Capping
Cellular Response To DNA Damage Stimulus
DNA Repair
Nucleotide-excision Repair
Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
DNA-templated Transcription, Termination
DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Transcription From RNA Polymerase I Promoter
Positive Regulation Of Cellular Biosynthetic Process
Metabolic Process
Transcription Elongation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase II Promoter
DNA-templated Transcription, Elongation
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Viral Process
Transcription From RNA Polymerase II Promoter
Nucleotide-excision Repair
7-methylguanosine MRNA Capping
7-methylguanosine RNA Capping
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Nucleotide-excision Repair, DNA Damage Removal
Transcription, DNA-templated
RNA Biosynthetic Process
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Regulation Of Viral Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
DNA Repair
Gene Expression
Nitrogen Compound Metabolic Process
Nucleotide-excision Repair, DNA Incision
Cellular Macromolecule Biosynthetic Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
MRNA Processing
UV Protection
Response To UV
DNA Catabolic Process
DNA Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Tagcloud
?
actb
appropriately
benchmark
chosen
confounding
gapdh
hormonal
hprt1
hyperglycemia
hyperglycemic
lean
myocardium
normalization
normalized
obesity
ppia
predisposition
reference
reproducibility
rpl13a
scrutiny
sdha
select
stably
tbp
tfrc
underline
ywhag
zucker
Tagcloud (Difference)
?
actb
appropriately
benchmark
chosen
confounding
gapdh
hormonal
hprt1
hyperglycemia
hyperglycemic
lean
myocardium
normalization
normalized
obesity
ppia
predisposition
reference
reproducibility
rpl13a
scrutiny
sdha
select
stably
tbp
tfrc
underline
ywhag
zucker
Tagcloud (Intersection)
?