POLR2A and CSH2

Number of citations of the paper that reports this interaction (PubMedID 9312053)
48

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		POLR2A	CSH2
Description		RNA polymerase II subunit A	chorionic somatomammotropin hormone 2
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Chromosome Nucleolus Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endomembrane System Vesicle
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding RNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Kinase Binding Ubiquitin Protein Ligase Binding 5'-3' RNA Polymerase Activity Metal Ion Binding Microfibril Binding Promoter-specific Chromatin Binding	Growth Hormone Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding
	Biological Process	RNA-templated Transcription DNA-templated Transcription DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing MRNA Transcription By RNA Polymerase II	Response To Nutrient Levels Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Myopia ( 27182965) Parkinson's disease progression (cognitive) ( 33958783) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 33547301) Height ( 25282103 31562340)
Interacting Genes		103 interacting genes: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 EIF4ENIF1 ELL ERCC5 ERCC6 ERCC8 ERG ESR1 FUS GRB2 GTF2B GTF2H4 H1-2 HNRNPF HTATSF1 IFTAP ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2L PPIG PPP1CA PPP2CA PQBP1 PRMT5 PRPF19 PTEN RNF10 SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUMO2 SUPT5H TAF10 TCEA1 TCERG1 TDRD3 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR XAB2 XRCC5 ZC3H4 ZNF74	8 interacting genes: MEOX2 POLR2A PTPN12 SGTB SMAD2 SMAD3 SMAD4 SMAD9
Entrez ID		5430	1443
HPRD ID		08916	06688
Ensembl ID		ENSG00000181222	ENSG00000213218
Uniprot IDs		A0AAG2TJB2 P24928	A0A0M6L0F6 A6NIT4 B1A4H9 P0DML3
PDB IDs		2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6IC8 6IC9 6O9L 6Q5Y 6XKB 6XRE 7EGB 7EGC 7LBM 7YCX 7Z1K 7Z42 8PM0 8PNP 8PNQ 8R3K 8R3L 8R60 8R65 9B9L 9EHZ 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleic Acid Metabolic Process Nucleus RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA Metabolic Process DNA Repair Regulation Of Cell Cycle Regulation Of DNA Repair DNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II MRNA Processing RNA Polymerase II, Core Complex DNA Damage Response Transcription Elongation By RNA Polymerase II Chromatin Binding Regulation Of Cell Cycle Process RNA Polymerase Binding Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Organization Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle	Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Embryonic Pattern Specification Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor R-SMAD Binding Activin Receptor Signaling Pathway Endoderm Development Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Mesoderm Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Transcription Regulator Complex Pericardium Development Response To Transforming Growth Factor Beta Trophoblast Cell Migration DNA-binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Roof Of Mouth Development Regulation Of Transforming Growth Factor Beta2 Production Embryonic Foregut Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Nodal Signaling Pathway Co-SMAD Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Secondary Palate Development Primary MiRNA Processing Developmental Growth Regulation Of Epithelial To Mesenchymal Transition Pattern Specification Process Transforming Growth Factor Beta Receptor Binding Response To Glucose Ameboidal-type Cell Migration Osteoblast Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Monosaccharide RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Carbohydrate Chromatin Regulation Of Extracellular Matrix Assembly Anterior/posterior Pattern Specification DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Adrenal Gland Development Positive Regulation Of Extracellular Matrix Organization
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