PCBP3 and PTBP2

Number of citations: 0 (PubMedID 16713569)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PCBP3	PTBP2
Name		poly(rC) binding protein 3	polypyrimidine tract binding protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome Ribonucleoprotein Complex	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding C-rich Single-stranded DNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
GWAS		A body shape index ( 34021172 ) Ankle injury ( 28957384 ) Daytime nap ( 33568662 ) Diffusing capacity of carbon monoxide ( 30694715 ) Insulin resistance/response ( 21901158 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Low myopia ( 33830181 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 32231278 ) Spatial processing ( 31596458 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Waist circumference adjusted for body mass index ( 34021172 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Anorexia nervosa ( 31308545 ) Autism spectrum disorder ( 30804558 ) BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 20935630 28892062 28448500 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically inactive individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Daytime nap ( 33568662 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) Headache ( 29397368 ) Hip circumference ( 25673412 ) Number of sexual partners ( 30643258 ) Reaction time ( 29844566 ) Regular attendance at a pub or social club ( 29970889 ) Schizophrenia ( 22688191 19571811 ) Smoking status (ever vs never smokers) ( 30643258 ) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398 ) Waist circumference ( 25673412 )
Interacting Genes		17 interacting genes: APOBEC3C CELF4 DDIT4L HNRNPLL KRT81 MATR3 PTBP1 PTBP2 PUF60 QKI RBM47 RNF4 RUVBL1 SNRPA SREK1 SRSF3 ZC3HAV1	26 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1
Entrez ID		54039	58155
HPRD ID		10534	12233
Ensembl ID		ENSG00000183570	ENSG00000117569
Uniprot IDs		P57721	A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		Not available	2CQ1 2MJU 4CQ1
GO Terms Enriched among Interactors		Nucleic Acid Binding MRNA Processing Regulation Of RNA Splicing RNA Splicing RNA Binding MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Macromolecule Metabolic Process Nucleus Ribonucleoprotein Complex Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytidine To Uridine Editing Base Conversion Or Substitution Editing Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process RNA Localization Regulation Of RNA Metabolic Process Regulation Of Metabolic Process MiRNA Binding Spliceosomal Complex Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of Retina Development In Camera-type Eye Negative Regulation Of Viral Genome Replication Positive Regulation Of Macromolecule Metabolic Process Poly-pyrimidine Tract Binding Protein-RNA Sequence-specific Adaptor Activity	Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression