PCBP3 and SRSF3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PCBP3	SRSF3
Name		poly(rC) binding protein 3	serine and arginine rich splicing factor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding C-rich Single-stranded DNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways		None	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
GWAS		A body shape index ( 34021172 ) Ankle injury ( 28957384 ) Daytime nap ( 33568662 ) Diffusing capacity of carbon monoxide ( 30694715 ) Insulin resistance/response ( 21901158 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Low myopia ( 33830181 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 32231278 ) Spatial processing ( 31596458 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Waist circumference adjusted for body mass index ( 34021172 )	Glaucoma (primary open-angle) ( 33627673 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		17 interacting genes: APOBEC3C CELF4 DDIT4L HNRNPLL KRT81 MATR3 PTBP1 PTBP2 PUF60 QKI RBM47 RNF4 RUVBL1 SNRPA SREK1 SRSF3 ZC3HAV1	40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ
Entrez ID		54039	6428
HPRD ID		10534	04530
Ensembl ID		ENSG00000183570	ENSG00000112081
Uniprot IDs		P57721	B2R6F3 P84103
PDB IDs		Not available	2I2Y 2I38 9ASQ
GO Terms Enriched among Interactors		Nucleic Acid Binding MRNA Processing Regulation Of RNA Splicing RNA Splicing RNA Binding MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Macromolecule Metabolic Process Nucleus Ribonucleoprotein Complex Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytidine To Uridine Editing Base Conversion Or Substitution Editing Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process RNA Localization Regulation Of RNA Metabolic Process Regulation Of Metabolic Process MiRNA Binding Spliceosomal Complex Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of Retina Development In Camera-type Eye Negative Regulation Of Viral Genome Replication Positive Regulation Of Macromolecule Metabolic Process Poly-pyrimidine Tract Binding Protein-RNA Sequence-specific Adaptor Activity	Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex