CLN8 and ZUP1

Number of citations of the paper that reports this interaction (PubMedID 23142642)
0

Data Source:
BioGRID (two hybrid)

		CLN8	ZUP1
Description		CLN8 transmembrane ER and ERGIC protein	zinc finger containing ubiquitin peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Ceramide Binding	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Adult Locomotory Behavior Regulation Of Cell Size Lipid Biosynthetic Process Macromolecule Catabolic Process Spinal Cord Motor Neuron Differentiation Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuron Apoptotic Process Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization Retinal Rod Cell Apoptotic Process
Pathways
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		31 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC USP40 YIPF6 ZUP1	9 interacting genes: ARHGAP45 CDKN2A CFTR CLN8 MMP14 PRMT5 RPS21 SHCBP1 UBC
Entrez ID		2055	221302
HPRD ID		06383	12840
Ensembl ID		ENSG00000182372	ENSG00000153975
Uniprot IDs		Q9UBY8	A0A0S2Z644 Q96AP4
PDB IDs			6EI1 6FGE
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Membrane Organization Membrane Organization Myelin Sheath Mitochondrial Outer Membrane Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Structural Constituent Of Myelin Sheath Regulation Of Membrane Permeability Central Nervous System Myelination Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Glial Cell Migration	Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-matrix Adhesion Ligase Inhibitor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Positive Regulation Of Macrophage Apoptotic Process P53 Binding Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Metabolic Process Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Regulation Of B Cell Activation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Proteolysis Senescence-associated Heterochromatin Focus Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell-matrix Adhesion Apoptotic Process Involved In Mammary Gland Involution Cytoplasm Regulation Of Signal Transduction By P53 Class Mediator Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Positive Regulation Of Monoatomic Anion Transport Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Response To Genistein GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Response To Odorant Histone H4R3 Methyltransferase Activity Peptidyl-arginine N-methylation Positive Regulation Of Dopamine Receptor Signaling Pathway Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Radial Spoke Head 1 Radial Spoke Assembly
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