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CLN8 and TUBB4A
Number of citations of the paper that reports this interaction (PubMedID
23142642
)
0
Data Source:
BioGRID
(two hybrid)
CLN8
TUBB4A
Description
CLN8 transmembrane ER and ERGIC protein
tubulin beta 4A class IVa
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Presynapse
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Cilium
Axoneme
Microtubule Cytoskeleton
Internode Region Of Axon
Cell Projection
Neuronal Cell Body
Myelin Sheath
Intercellular Bridge
Extracellular Exosome
Mitotic Spindle
Molecular Function
Protein Binding
Ceramide Binding
Nucleotide Binding
GTPase Activity
Structural Constituent Of Cytoskeleton
Calcium Ion Binding
Protein Binding
GTP Binding
Metal Ion Binding
Biological Process
Phospholipid Metabolic Process
Ceramide Metabolic Process
Lipid Transport
Apoptotic Process
Mitochondrial Membrane Organization
Lysosome Organization
Nervous System Development
Visual Perception
Adult Walking Behavior
Cholesterol Metabolic Process
Associative Learning
Adult Locomotory Behavior
Regulation Of Cell Size
Lipid Biosynthetic Process
Macromolecule Catabolic Process
Spinal Cord Motor Neuron Differentiation
Somatic Motor Neuron Differentiation
Protein Catabolic Process
Social Behavior
Negative Regulation Of Neuron Apoptotic Process
Photoreceptor Cell Maintenance
Negative Regulation Of Proteolysis
Ceramide Biosynthetic Process
Musculoskeletal Movement
Neuromuscular Process Controlling Posture
Neuromuscular Process Controlling Balance
Neuron Apoptotic Process
Glutamate Reuptake
Lipid Homeostasis
Retina Development In Camera-type Eye
Neurofilament Cytoskeleton Organization
Retinal Rod Cell Apoptotic Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Negative Regulation Of Microtubule Polymerization
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Epothilone D
Patupilone
CYT997
ZEN-012
Artenimol
Diseases
Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS
Eye morphology (
29921221
)
Gaucher disease severity (
22388998
)
Systolic blood pressure (
30224653
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Left-handedness (
32989287
)
Left–right brain asymmetry (
33723403
)
Interacting Genes
31 interacting genes:
ARL6IP5
BNIP3
BNIP3L
CD9
CYB5B
ERG28
FZD7
GABARAPL2
GPM6B
MTX1
NDRG2
PDIA6
PLP1
PLP2
PTPRN
RRP15
RTN4
SELENOK
SPCS2
STX8
TMEM107
TMEM11
TMEM128
TMEM134
TMEM147
TMEM14A
TUBB4A
UBC
USP40
YIPF6
ZUP1
15 interacting genes:
BMPR2
CEBPA
CLN8
FNDC3B
LINC01554
NEAT1
NR4A1
OGT
RBM11
RSPH1
SELENOF
STAU1
STK11
SUMO2
YWHAG
Entrez ID
2055
10382
HPRD ID
06383
04045
Ensembl ID
ENSG00000182372
ENSG00000104833
Uniprot IDs
Q9UBY8
M0QZL7
M0R1I1
M0R278
P04350
PDB IDs
Enriched GO Terms of Interacting Partners
?
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum
Membrane
Negative Regulation Of Membrane Potential
Negative Regulation Of Mitochondrial Membrane Potential
Mitochondrial Membrane Organization
Membrane Organization
Myelin Sheath
Mitochondrial Outer Membrane
Mitochondrion Organization
Mitochondrial Outer Membrane Permeabilization
Mitochondrial Protein Catabolic Process
Regulation Of Mitochondrial Membrane Permeability
Structural Constituent Of Myelin Sheath
Regulation Of Membrane Permeability
Central Nervous System Myelination
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Mitochondrial Envelope
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Response To Oxidative Stress
Negative Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Membrane Permeability
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Membrane Permeability
Glial Cell Migration
Non-canonical Inflammasome Complex Assembly
LncRNA-mediated Post-transcriptional Gene Silencing
Cellular Developmental Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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