CLN8 and GPM6B

Number of citations of the paper that reports this interaction (PubMedID 23142642)
0

Data Source:
BioGRID (two hybrid)

		CLN8	GPM6B
Description		CLN8 transmembrane ER and ERGIC protein	glycoprotein M6B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse	Plasma Membrane Membrane Myelin Sheath Membrane Raft
	Molecular Function	Protein Binding Ceramide Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Adult Locomotory Behavior Regulation Of Cell Size Lipid Biosynthetic Process Macromolecule Catabolic Process Spinal Cord Motor Neuron Differentiation Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuron Apoptotic Process Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization Retinal Rod Cell Apoptotic Process	Ossification Nervous System Development Protein Transport Central Nervous System Myelination Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Serotonin Uptake Regulation Of Focal Adhesion Assembly Axon Development Extracellular Matrix Assembly Negative Regulation Of Protein Localization To Cell Surface
Pathways
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Delayed reward discounting ( 29230059) Glaucoma (primary open-angle) ( 33627673)
Interacting Genes		31 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC USP40 YIPF6 ZUP1	7 interacting genes: CLN8 EGFR ERBB2 ERGIC3 MTNR1B SLC6A4 STX1A
Entrez ID		2055	2824
HPRD ID		06383	02082
Ensembl ID		ENSG00000182372	ENSG00000046653
Uniprot IDs		Q9UBY8	B7Z613 Q13491 Q59FD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Membrane Organization Membrane Organization Myelin Sheath Mitochondrial Outer Membrane Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Structural Constituent Of Myelin Sheath Regulation Of Membrane Permeability Central Nervous System Myelination Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Glial Cell Migration	ERBB2-EGFR Signaling Pathway Regulation Of Protein Localization Neurotransmitter Transport Presynaptic Membrane Neurotransmitter Reuptake Regulation Of Establishment Of Protein Localization ERBB2 Signaling Pathway Neurotransmitter Uptake Learning Or Memory Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Cognition Response To Epidermal Growth Factor Negative Regulation Of Apoptotic Process Endosome Membrane Negative Regulation Of Programmed Cell Death Neuron Differentiation Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Regulation Of Thalamus Size Positive Regulation Of Serotonin Secretion Cocaine Binding Myosin Head/neck Binding Regulation Of Membrane Potential Regulation Of Protein Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding Ruffle Membrane Shc-EGFR Complex Negative Regulation Of Multicellular Organismal Process Associative Learning Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process ERBB3:ERBB2 Complex Serotonergic Synapse Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Retrograde Transporter Complex, Golgi To ER Response To Estradiol Regulation Of Cellular Localization Localization Within Membrane Amino Acid Transport Regulation Of Nervous System Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Protein Tyrosine Kinase Activity
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