CLN8 and SPCS2

Number of citations of the paper that reports this interaction (PubMedID 23142642)
0

Data Source:
BioGRID (two hybrid)

		CLN8	SPCS2
Description		CLN8 transmembrane ER and ERGIC protein	signal peptidase complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Ceramide Binding	Protein Binding
	Biological Process	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Adult Locomotory Behavior Regulation Of Cell Size Lipid Biosynthetic Process Macromolecule Catabolic Process Spinal Cord Motor Neuron Differentiation Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuron Apoptotic Process Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization Retinal Rod Cell Apoptotic Process	Signal Peptide Processing Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		31 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC USP40 YIPF6 ZUP1	6 interacting genes: ATP13A2 CLN8 EGFR FNDC3B STMN3 TEFM
Entrez ID		2055	9789
HPRD ID		06383	15435
Ensembl ID		ENSG00000182372	ENSG00000118363
Uniprot IDs		Q9UBY8	Q15005
PDB IDs			7P2P 7P2Q
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Membrane Organization Membrane Organization Myelin Sheath Mitochondrial Outer Membrane Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Structural Constituent Of Myelin Sheath Regulation Of Membrane Permeability Central Nervous System Myelination Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Glial Cell Migration	Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Protein Metabolic Process Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Transcription Elongation By Mitochondrial RNA Polymerase Positive Regulation Of Mitochondrial Transcription Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Vacuole Organization Lipid Homeostasis Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Negative Regulation Of Rac Protein Signal Transduction Retinal Cell Apoptotic Process Polyamine Transmembrane Transport ERBB2-EGFR Signaling Pathway Ceramide Binding Regulation Of Cellular Component Size Regulation Of Neuron Apoptotic Process Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Transcription Elongation Factor Activity Crossover Junction DNA Endonuclease Activity Learning Or Memory Salivary Gland Morphogenesis Neurofilament Cytoskeleton Organization L-glutamate Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Mitochondrial DNA Replication Regulation Of Mitochondrial Transcription
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