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ITGB4 and MET
Number of citations of the paper that reports this interaction (PubMedID
11733063
)
0
Data Source:
HPRD
(in vivo)
ITGB4
MET
Description
integrin subunit beta 4
MET proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Basement Membrane
Nucleolus
Plasma Membrane
Focal Adhesion
Integrin Complex
Basal Plasma Membrane
Cell Surface
Membrane
Cell Junction
Hemidesmosome
Cell Leading Edge
Nuclear Membrane
Receptor Complex
Extracellular Exosome
Anchoring Junction
Extracellular Region
Plasma Membrane
Basal Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Postsynapse
Molecular Function
G Protein-coupled Receptor Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Metal Ion Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Hepatocyte Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Semaphorin Receptor Activity
Protein Phosphatase Binding
Identical Protein Binding
Molecular Function Activator Activity
Biological Process
Autophagy
Cell Communication
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Response To Wounding
Cell Migration
Myelination In Peripheral Nervous System
Hemidesmosome Assembly
Peripheral Nervous System Myelin Formation
Cell Adhesion Mediated By Integrin
Nail Development
Skin Morphogenesis
Filopodium Assembly
Mesodermal Cell Differentiation
Cell Motility
Trophoblast Cell Migration
Cell-cell Adhesion
Endothelial Cell Morphogenesis
Liver Development
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Neuron Differentiation
Pancreas Development
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Cell Development
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Positive Chemotaxis
Negative Regulation Of Stress Fiber Assembly
Excitatory Postsynaptic Potential
Establishment Of Skin Barrier
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Semaphorin-plexin Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
Assembly of collagen fibrils and other multimeric structures
Laminin interactions
Syndecan interactions
Type I hemidesmosome assembly
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Drug-mediated inhibition of MET activation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
R1295
Sunitinib
K-252a
SGX-523
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
AMG-208
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
Crizotinib
Cabozantinib
Capmatinib
Tivozanib
Fostamatinib
Tivantinib
Brigatinib
Amuvatinib
Tepotinib
Amivantamab
Diseases
Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
Cholangiocarcinoma
Gastric cancer
Renal cell carcinoma
GWAS
Age at first sexual intercourse (
34211149
)
Alanine aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
HDL cholesterol levels (
28334899
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
28017375
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (beta blocking agents) (
31015401
)
Multiple sclerosis (severity) (
19010793
)
PR segment duration (
24850809
)
Pulse pressure (
30578418
)
Resting heart rate (
27798624
29769521
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
60 interacting genes:
ADAMTSL4
ALOX12
APPBP2
ATXN1
CLCA1
CLCA2
COL17A1
CYSRT1
DST
ECM1
EIF6
ERBB2
ERBIN
FYN
GRB2
HOXA1
ITGA6
KPRP
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP15-1
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-1
KRTAP4-2
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MET
MID2
MTUS2
MYF5
NBPF19
NOTCH2NLA
PLEC
PLSCR4
POU2AF1
PRKCA
PRKCD
PTK2
SDC2
SDC3
SHC1
SREBF2
TGM1
TRIP6
VIM
YES1
YWHAB
YWHAQ
112 interacting genes:
ABL2
BAG1
BCAR3
BLK
BTK
CASP3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2B
CNR1
CRK
CTNNB1
CTTN
DAPK3
DCN
DNAJA3
EGFR
EPHA2
ERBB2
FAS
FES
FGFR4
FGR
FZR1
GAB1
GLIS2
GLMN
GRB14
GRB2
GRB7
HCK
HGF
HGS
HSH2D
INPP5D
INPPL1
ITGB1
ITGB4
ITK
KDELR2
LATS2
LCK
LYN
MAP2K3
MAP2K5
MATK
MUC20
MYC
NCK1
NCK2
NF2
PCBD2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PLXNB1
PTK6
PTPN11
PTPRB
PTPRJ
RAF1
RANBP10
RANBP9
RASA1
RASSF1
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA2
SMC1A
SNAPIN
SNX2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPSB1
SRC
STAP1
STAT3
STK11
SYK
TEC
TERT
TNS1
TNS2
TNS3
TNS4
TP53
TXK
VAV1
VAV2
VAV3
YES1
ZAP70
Entrez ID
3691
4233
HPRD ID
00946
01280
Ensembl ID
ENSG00000132470
ENSG00000105976
Uniprot IDs
B7ZLD8
P16144
B4DLF5
E6Y365
P08581
PDB IDs
1QG3
2YRZ
3F7P
3F7Q
3F7R
3FQ4
3FSO
3H6A
4Q58
4WTW
4WTX
6GVK
6GVL
1FYR
1R0P
1R1W
1SHY
1SSL
2G15
2RFN
2RFS
2UZX
2UZY
2WD1
2WGJ
2WKM
3A4P
3BUX
3C1X
3CCN
3CD8
3CE3
3CTH
3CTJ
3DKC
3DKF
3DKG
3EFJ
3EFK
3F66
3F82
3I5N
3L8V
3LQ8
3Q6U
3Q6W
3QTI
3R7O
3RHK
3U6H
3U6I
3VW8
3ZBX
3ZC5
3ZCL
3ZXZ
3ZZE
4AOI
4AP7
4DEG
4DEH
4DEI
4EEV
4GG5
4GG7
4IWD
4K3J
4KNB
4MXC
4O3T
4O3U
4R1V
4R1Y
4XMO
4XYF
5DG5
5EOB
5EYC
5EYD
5HLW
5HNI
5HO6
5HOA
5HOR
5HTI
5LSP
5T3Q
5UAB
5UAD
5YA5
6GCU
6I04
6SD9
6SDC
6SDD
6SDE
6UBW
6WVZ
7B3Q
7B3T
7B3V
7B3W
7B3Z
7B40
7B41
7B42
7B43
7B44
7MO7
7MO8
7MO9
7MOA
7MOB
7V3R
7V3S
7Y4T
7Y4U
8AN8
8ANS
8AU3
8AU5
8AW1
8GVJ
8K78
8OUU
8OUV
8OV7
8OVZ
8OW3
8OWG
9C1R
9IVB
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Identical Protein Binding
Hemidesmosome
Cytosol
Establishment Of Skin Barrier
Cell-substrate Junction Assembly
Skin Epidermis Development
Cell-substrate Junction Organization
Epidermis Development
Hemidesmosome Assembly
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Focal Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Basal Plasma Membrane
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
ERBB Signaling Pathway
Anchoring Junction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Signaling Pathway
Protein Kinase C Signaling
Ephrin Receptor Binding
Regulation Of Reactive Oxygen Species Metabolic Process
Intermediate Filament Organization
Regulation Of Platelet Aggregation
Neurotrophin TRKA Receptor Binding
Cell Junction Organization
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Response To Fluid Shear Stress
Cell Junction Assembly
Regulation Of Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
CD4 Receptor Binding
Immune Effector Process
Structural Constituent Of Cytoskeleton
Protein Binding
Response To Fluid Shear Stress
Enzyme Binding
T Cell Costimulation
Negative Regulation Of Glial Cell Apoptotic Process
Phosphotyrosine Residue Binding
Negative Regulation Of Platelet Aggregation
Intermediate Filament Cytoskeleton
Peptidyl-tyrosine Phosphorylation
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Adhesion
Cytosol
ERBB Signaling Pathway
Immune Response-activating Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune System Process
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cell Activation
Peptidyl-tyrosine Phosphorylation
Leukocyte Activation
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Negative Regulation Of Signal Transduction
Protein Kinase Activity
Lymphocyte Activation
Activation Of Immune Response
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Immune System Process
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Immune System Process
Fc Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Regulation Of MAPK Cascade
T Cell Activation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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