ITGB4 and ALOX12

Number of citations of the paper that reports this interaction (PubMedID 26037302)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ITGB4	ALOX12
Description		integrin subunit beta 4	arachidonate 12-lipoxygenase, 12S type
Image
GO Annotations	Cellular Component	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Membrane Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome Anchoring Junction	Cytoplasm Cytosol Membrane Sarcolemma Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Metal Ion Binding Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity Dioxygenase Activity
	Biological Process	Autophagy Cell Communication Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Myelination In Peripheral Nervous System Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration Cell-cell Adhesion	Lipid Metabolic Process Fatty Acid Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Arachidonate Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Biosynthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
Drugs		R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Mean platelet volume ( 32888494)
Interacting Genes		60 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3691	239
HPRD ID		00946	01066
Ensembl ID		ENSG00000132470	ENSG00000108839
Uniprot IDs		B7ZLD8 P16144	P18054
PDB IDs		1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL	3D3L 8GHB 8GHC 8GHD 8GHE
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Hemidesmosome Cytosol Establishment Of Skin Barrier Cell-substrate Junction Assembly Skin Epidermis Development Cell-substrate Junction Organization Epidermis Development Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway ERBB Signaling Pathway Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Protein Kinase C Signaling Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Organization Regulation Of Platelet Aggregation Neurotrophin TRKA Receptor Binding Cell Junction Organization Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Cell Junction Assembly Regulation Of Cell-cell Adhesion Integrin-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Immune Effector Process Structural Constituent Of Cytoskeleton Protein Binding Response To Fluid Shear Stress Enzyme Binding T Cell Costimulation Negative Regulation Of Glial Cell Apoptotic Process Phosphotyrosine Residue Binding Negative Regulation Of Platelet Aggregation Intermediate Filament Cytoskeleton Peptidyl-tyrosine Phosphorylation	Intermediate Filament Phosphatidylethanolamine Metabolic Process Peripheral Nervous System Myelin Formation Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament Polymerization Or Depolymerization Keratinization Keratin Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Lumen Site Of Double-strand Break Negative Regulation Of Multicellular Organismal Process Structural Constituent Of Nuclear Lamina Cellular Senescence Phosphatidylcholine Metabolic Process Positive Regulation Of Eosinophil Differentiation Negative Regulation Of Neutrophil Differentiation Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Epidermis Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Piccolo Histone Acetyltransferase Complex Hemidesmosome Assembly Nail Development Neuregulin Binding Tissue Development Structural Molecule Activity Negative Regulation Of Cell Population Proliferation Lamin Filament Perinuclear Region Of Cytoplasm Nuclear Pore Localization Intestinal Stem Cell Homeostasis Ubiquitin-protein Transferase Regulator Activity Positive Regulation Of Protein Acetylation Positive Regulation Of Aggrephagy Positive Regulation Of Leukocyte Differentiation Trophoblast Cell Migration Lipid Droplet Disassembly Hemidesmosome Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Granulocyte Differentiation
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