ITGB4 and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ITGB4	POU2AF1
Description		integrin subunit beta 4	POU class 2 homeobox associating factor 1
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GO Annotations	Cellular Component	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Membrane Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome Anchoring Junction	Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding POU Domain Binding
	Biological Process	Autophagy Cell Communication Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Myelination In Peripheral Nervous System Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration Cell-cell Adhesion	Germinal Center B Cell Differentiation Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus
Pathways		Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Brain morphology (MOSTest) ( 32665545) Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		60 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ	54 interacting genes: CCDC120 CIMIP2B DGCR6L FOXD2 GATA2 GPS2 GTF2H1 GTF2I HEMK1 HGS HOXC8 HOXC9 ITGB4 KLHL38 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 MEIS2 MSX2 NAB1 NDUFAF3 NOTCH1 OTX1 PAX8 PITX2 POGZ POU2F1 POU2F2 PTPN11 RAMAC RBM24 RHOXF2 ROR2 SCAND1 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK TBX6 TENT5B TFG TLX3 USP2 VGLL3 VPS37C YPEL3 ZNF414 ZNF581
Entrez ID		3691	5450
HPRD ID		00946	03126
Ensembl ID		ENSG00000132470	ENSG00000110777
Uniprot IDs		B7ZLD8 P16144	Q16633
PDB IDs		1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL	1CQT
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Hemidesmosome Cytosol Establishment Of Skin Barrier Cell-substrate Junction Assembly Skin Epidermis Development Cell-substrate Junction Organization Epidermis Development Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway ERBB Signaling Pathway Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Protein Kinase C Signaling Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Organization Regulation Of Platelet Aggregation Neurotrophin TRKA Receptor Binding Cell Junction Organization Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Cell Junction Assembly Regulation Of Cell-cell Adhesion Integrin-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Immune Effector Process Structural Constituent Of Cytoskeleton Protein Binding Response To Fluid Shear Stress Enzyme Binding T Cell Costimulation Negative Regulation Of Glial Cell Apoptotic Process Phosphotyrosine Residue Binding Negative Regulation Of Platelet Aggregation Intermediate Filament Cytoskeleton Peptidyl-tyrosine Phosphorylation	DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Pattern Specification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Serotonin Transport Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Pyrimidine Nucleoside Transmembrane Transporter Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intermediate Filament Anterior/posterior Pattern Specification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Putrescine Transmembrane Transporter Activity Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Nephron Tubule Development Embryonic Morphogenesis Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Renal Tubule Development Kidney Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Embryonic Hindlimb Morphogenesis Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport
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