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ITGB4 and YWHAB
Number of citations of the paper that reports this interaction (PubMedID
12919677
)
0
Data Source:
HPRD
(in vitro, two hybrid)
ITGB4
YWHAB
Description
integrin subunit beta 4
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations
Cellular Component
Basement Membrane
Nucleolus
Plasma Membrane
Focal Adhesion
Integrin Complex
Basal Plasma Membrane
Cell Surface
Membrane
Cell Junction
Hemidesmosome
Cell Leading Edge
Nuclear Membrane
Receptor Complex
Extracellular Exosome
Anchoring Junction
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
G Protein-coupled Receptor Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Metal Ion Binding
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Biological Process
Autophagy
Cell Communication
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Response To Wounding
Cell Migration
Myelination In Peripheral Nervous System
Hemidesmosome Assembly
Peripheral Nervous System Myelin Formation
Cell Adhesion Mediated By Integrin
Nail Development
Skin Morphogenesis
Filopodium Assembly
Mesodermal Cell Differentiation
Cell Motility
Trophoblast Cell Migration
Cell-cell Adhesion
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Assembly of collagen fibrils and other multimeric structures
Laminin interactions
Syndecan interactions
Type I hemidesmosome assembly
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
R1295
Copper
Phenethyl Isothiocyanate
Diseases
Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
60 interacting genes:
ADAMTSL4
ALOX12
APPBP2
ATXN1
CLCA1
CLCA2
COL17A1
CYSRT1
DST
ECM1
EIF6
ERBB2
ERBIN
FYN
GRB2
HOXA1
ITGA6
KPRP
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP15-1
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-1
KRTAP4-2
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MET
MID2
MTUS2
MYF5
NBPF19
NOTCH2NLA
PLEC
PLSCR4
POU2AF1
PRKCA
PRKCD
PTK2
SDC2
SDC3
SHC1
SREBF2
TGM1
TRIP6
VIM
YES1
YWHAB
YWHAQ
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
3691
7529
HPRD ID
00946
03184
Ensembl ID
ENSG00000132470
ENSG00000166913
Uniprot IDs
B7ZLD8
P16144
P31946
V9HWD6
PDB IDs
1QG3
2YRZ
3F7P
3F7Q
3F7R
3FQ4
3FSO
3H6A
4Q58
4WTW
4WTX
6GVK
6GVL
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Identical Protein Binding
Hemidesmosome
Cytosol
Establishment Of Skin Barrier
Cell-substrate Junction Assembly
Skin Epidermis Development
Cell-substrate Junction Organization
Epidermis Development
Hemidesmosome Assembly
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Focal Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Basal Plasma Membrane
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
ERBB Signaling Pathway
Anchoring Junction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Signaling Pathway
Protein Kinase C Signaling
Ephrin Receptor Binding
Regulation Of Reactive Oxygen Species Metabolic Process
Intermediate Filament Organization
Regulation Of Platelet Aggregation
Neurotrophin TRKA Receptor Binding
Cell Junction Organization
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Response To Fluid Shear Stress
Cell Junction Assembly
Regulation Of Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
CD4 Receptor Binding
Immune Effector Process
Structural Constituent Of Cytoskeleton
Protein Binding
Response To Fluid Shear Stress
Enzyme Binding
T Cell Costimulation
Negative Regulation Of Glial Cell Apoptotic Process
Phosphotyrosine Residue Binding
Negative Regulation Of Platelet Aggregation
Intermediate Filament Cytoskeleton
Peptidyl-tyrosine Phosphorylation
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
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