ITGB4 and CLCA2

Number of citations of the paper that reports this interaction (PubMedID 12110680)
0

Data Source:
HPRD (in vitro, in vivo)

		ITGB4	CLCA2
Description		integrin subunit beta 4	chloride channel accessory 2
Image			No pdb structure
GO Annotations	Cellular Component	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Membrane Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome Anchoring Junction	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Basal Plasma Membrane Membrane Cell Junction Nuclear Membrane Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Ligand-gated Monoatomic Ion Channel Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Autophagy Cell Communication Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Myelination In Peripheral Nervous System Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration Cell-cell Adhesion	Proteolysis Monoatomic Ion Transport Chloride Transport Cell Adhesion Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Stimuli-sensing channels
Drugs		R1295
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Crohn's disease-related phenotypes ( 25557950) Hallux valgus ( 32131869)
Interacting Genes		60 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ	1 interacting genes: ITGB4
Entrez ID		3691	9635
HPRD ID		00946	04923
Ensembl ID		ENSG00000132470	ENSG00000137975
Uniprot IDs		B7ZLD8 P16144	Q9UQC9
PDB IDs		1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Identical Protein Binding Hemidesmosome Cytosol Establishment Of Skin Barrier Cell-substrate Junction Assembly Skin Epidermis Development Cell-substrate Junction Organization Epidermis Development Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway ERBB Signaling Pathway Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Protein Kinase C Signaling Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Organization Regulation Of Platelet Aggregation Neurotrophin TRKA Receptor Binding Cell Junction Organization Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Cell Junction Assembly Regulation Of Cell-cell Adhesion Integrin-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Immune Effector Process Structural Constituent Of Cytoskeleton Protein Binding Response To Fluid Shear Stress Enzyme Binding T Cell Costimulation Negative Regulation Of Glial Cell Apoptotic Process Phosphotyrosine Residue Binding Negative Regulation Of Platelet Aggregation Intermediate Filament Cytoskeleton Peptidyl-tyrosine Phosphorylation	Hemidesmosome Assembly Hemidesmosome Nail Development Peripheral Nervous System Myelin Formation Neuregulin Binding Trophoblast Cell Migration Skin Morphogenesis Myelin Assembly Insulin-like Growth Factor I Binding Mesodermal Cell Differentiation Myelination In Peripheral Nervous System Filopodium Assembly Integrin Complex Cell Adhesion Mediated By Integrin Cell-substrate Junction Organization Cell-substrate Junction Assembly Cell Leading Edge Basal Plasma Membrane G Protein-coupled Receptor Binding Basement Membrane Myelination Axon Ensheathment Integrin-mediated Signaling Pathway Cell-matrix Adhesion Ameboidal-type Cell Migration Integrin Binding Cell-substrate Adhesion Receptor Complex Cell Junction Response To Wounding Cell Junction Assembly Nuclear Membrane Autophagy Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Anchoring Junction Focal Adhesion Cell Junction Organization
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