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CD28
Description
CD28 molecule
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Protein Complex Involved In Cell Adhesion
Molecular Function
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Cytokine Production
Immune System Process
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Transcription By RNA Polymerase II
Immune Response
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
CD4-positive, Alpha-beta T Cell Proliferation
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of T Cell Proliferation
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
27992413
23603763
)
Rheumatoid arthritis (
24390342
30423114
23143596
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Novel Interacting Genes
8 novel interacting genes:
AP1M1
BCS1L
CAND1
CFLAR
CTLA4
SEC14L2
WBP2NL
YAP1
Interacting Genes
17 interacting genes:
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
Entrez ID
940
HPRD ID
01727
Ensembl ID
ENSG00000178562
Uniprot IDs
B4E0L1
P10747
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
7PPN
7VU5
8S6Z
8W2V
Enriched GO Terms of Interacting Partners
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T Cell Activation
Lymphocyte Activation
Cell Activation
Leukocyte Activation
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
T Cell Differentiation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Mononuclear Cell Differentiation
B Cell Receptor Signaling Pathway
Gamma-delta T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune System Process
Leukocyte Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Lymphocyte Differentiation
Regulation Of T Cell Activation
Neurotrophin TRKA Receptor Binding
Positive Regulation Of T Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Interleukin-2 Production
Phosphatidylinositol 3-kinase Complex, Class IA
Alpha-beta T Cell Activation
Immune Response
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cytokine Production
Regulation Of Lymphocyte Activation
T Cell Costimulation
Immune Response-activating Signaling Pathway
Regulation Of Immune System Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Activation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Mononuclear Cell Proliferation
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Hemopoiesis
Positive Regulation Of Metabolic Process
Regulation Of Interleukin-2 Production
Regulation Of Leukocyte Proliferation
Intracellular Signal Transduction
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