CD28 and CD86

Number of citations of the paper that reports this interaction (PMID 7513726)
11

Data Source:
HPRD (in vivo)

		CD28	CD86
Gene Name		CD28 molecule	CD86 molecule
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protease Binding SH3/SH2 Adaptor Activity Protein Binding Coreceptor Activity Identical Protein Binding	Receptor Activity Receptor Binding Protein Binding Coreceptor Activity
	Biological Process	Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Response To Yeast Toll-like Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Negative Regulation Of T Cell Anergy Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Viral Process T Cell Costimulation Response To Interferon-gamma Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Cellular Response To Cytokine Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression CD28 co-stimulation Host Interactions of HIV factors CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR CD28 dependent Vav1 pathway Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Antithymocyte globulin Abatacept Belatacept
Diseases
GWAS		Celiac disease ( 20190752) Graves' disease ( 21841780)	Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		17 interactors: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC	6 interactors: CD28 CD80 CTLA4 ECE2 MARCH8 PARP1
Entrez ID		940	942
HPRD ID		01727	03011
Ensembl ID		ENSG00000178562	ENSG00000114013
Uniprot IDs		B4E0L1 P10747	A8K632 P42081
PDB IDs		1YJD	1I85 1NCN
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Defense Response Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Regulation Of Cell Activation Immune System Process Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Phosphorus Metabolic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Activation Leukocyte Aggregation Response To Stress Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Viral Process Positive Regulation Of Signal Transduction	T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cytokine Biosynthetic Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Immune Response Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Regulatory T Cell Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T-helper 1 Cell Differentiation
Tagcloud ?		accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		accelerated allows augment b7 catalytically cd28re composite concert consistently converge element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?		costimulatory