CD28 and DUSP14

Number of citations of the paper that reports this interaction (PMID 11123293)
8

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CD28	DUSP14
Gene Name		CD28 molecule	dual specificity phosphatase 14
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protease Binding SH3/SH2 Adaptor Activity Protein Binding Coreceptor Activity Identical Protein Binding	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Inactivation Of MAPK Activity Peptidyl-tyrosine Dephosphorylation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression CD28 co-stimulation Host Interactions of HIV factors CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR CD28 dependent Vav1 pathway Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Graves' disease ( 21841780)	Ovarian cancer ( 23535730)
Protein-Protein Interactions		17 interactors: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC	4 interactors: CD28 ISYNA1 SPERT UCHL5
Entrez ID		940	11072
HPRD ID		01727	09427
Ensembl ID		ENSG00000178562	ENSG00000161326
Uniprot IDs		B4E0L1 P10747	O95147 Q6FI36
PDB IDs		1YJD	2WGP
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Defense Response Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Regulation Of Cell Activation Immune System Process Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Phosphorus Metabolic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Activation Leukocyte Aggregation Response To Stress Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Viral Process Positive Regulation Of Signal Transduction	Inositol Biosynthetic Process Regulatory T Cell Differentiation Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Thymic T Cell Selection Cellular Response To Growth Factor Stimulus Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Response To Growth Factor Inositol Metabolic Process Positive Regulation Of Viral Genome Replication Forebrain Morphogenesis Thymic T Cell Selection Lateral Ventricle Development Regulation Of Interleukin-2 Biosynthetic Process Cytokine Biosynthetic Process Positive Regulation Of Isotype Switching Regulation Of Defense Response To Virus By Virus Cytokine Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Isotype Switching Positive Regulation Of Interleukin-2 Production Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Mitotic Nuclear Division T Cell Selection Brain Morphogenesis Ventricular System Development Inositol Phosphate Metabolic Process
Tagcloud ?		accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream	attenuated autoimmune classified deficiency deficient dephosphorylated dual encephalomyelitis enhanced hairpin ikappab immune inactivation inhibiting interacted jnk mapks mkp6 negatively phosphatase remain responses ser susceptible tab1 tak1 tcr tgf upon
Tagcloud (Difference) ?		accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust transactivation upstream	attenuated autoimmune classified deficiency deficient dephosphorylated dual encephalomyelitis enhanced hairpin immune inactivation inhibiting interacted jnk mapks mkp6 negatively phosphatase remain responses ser susceptible tab1 tak1 tgf upon
Tagcloud (Intersection) ?		ikappab tcr