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CD28 and DUSP14
Number of citations of the paper that reports this interaction (PubMedID
11123293
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
CD28
DUSP14
Description
CD28 molecule
dual specificity phosphatase 14
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Protein Complex Involved In Cell Adhesion
Cytoplasm
Molecular Function
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
RNA Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Biological Process
Positive Regulation Of Cytokine Production
Immune System Process
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Transcription By RNA Polymerase II
Immune Response
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
CD4-positive, Alpha-beta T Cell Proliferation
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of T Cell Proliferation
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
27992413
23603763
)
Rheumatoid arthritis (
24390342
30423114
23143596
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Monocyte count (
27863252
32888494
)
Ovarian cancer (
23535730
)
Platelet count (
27863252
32888494
)
Plateletcrit (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
17 interacting genes:
CD247
CD4
CD80
CD86
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
17 interacting genes:
AATK
CBY2
CD28
EPHA1
EPHA2
ERBB2
ERBB3
ERBB4
FGFR2
IGF1R
ISYNA1
LMTK2
PRMT5
PTK7
ROR1
ROR2
UCHL5
Entrez ID
940
11072
HPRD ID
01727
09427
Ensembl ID
ENSG00000178562
ENSG00000276023
Uniprot IDs
B4E0L1
P10747
O95147
Q6FI36
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
7PPN
7VU5
8S6Z
8W2V
2WGP
Enriched GO Terms of Interacting Partners
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T Cell Activation
Lymphocyte Activation
Cell Activation
Leukocyte Activation
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
T Cell Differentiation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Mononuclear Cell Differentiation
B Cell Receptor Signaling Pathway
Gamma-delta T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune System Process
Leukocyte Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Lymphocyte Differentiation
Regulation Of T Cell Activation
Neurotrophin TRKA Receptor Binding
Positive Regulation Of T Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Interleukin-2 Production
Phosphatidylinositol 3-kinase Complex, Class IA
Alpha-beta T Cell Activation
Immune Response
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cytokine Production
Regulation Of Lymphocyte Activation
T Cell Costimulation
Immune Response-activating Signaling Pathway
Regulation Of Immune System Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Activation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Mononuclear Cell Proliferation
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Hemopoiesis
Positive Regulation Of Metabolic Process
Regulation Of Interleukin-2 Production
Regulation Of Leukocyte Proliferation
Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Receptor Complex
Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
ATP Binding
Coreceptor Activity
Enzyme-linked Receptor Protein Signaling Pathway
Transferase Activity
Nucleotide Binding
Peptidyl-tyrosine Phosphorylation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
ERBB3:ERBB2 Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
ERBB2 Signaling Pathway
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of MAPK Cascade
Neuregulin Receptor Activity
Protein Autophosphorylation
Regulation Of ERK1 And ERK2 Cascade
ErbB-3 Class Receptor Binding
ERBB2-ERBB4 Signaling Pathway
Growth Factor Binding
Protein Phosphorylation
Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Development
Animal Organ Development
Mesenchyme Development
Phosphorylation
ERBB2-ERBB3 Signaling Pathway
Glial Cell Development
ERBB3 Signaling Pathway
ERBB4 Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Lung-associated Mesenchyme Development
Basal Plasma Membrane
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Wound Healing
ERBB Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Ephrin Receptor Activity
Heart Development
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Tagcloud (Intersection)
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