MET and MUC20

Number of citations of the paper that reports this interaction (PMID 15314156)
8

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MET	MUC20
Gene Name		MET proto-oncogene, receptor tyrosine kinase	mucin 20, cell surface associated
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Golgi Lumen Basal Plasma Membrane Apical Plasma Membrane Microvillus Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Activation Of MAPK Activity Endothelial Cell Morphogenesis Liver Development Placenta Development Signal Transduction Cell Surface Receptor Signaling Pathway Axon Guidance Brain Development Skeletal Muscle Tissue Development Cell Proliferation Positive Regulation Of Glucose Transport Muscle Cell Migration Myotube Differentiation Peptidyl-tyrosine Phosphorylation Adult Behavior Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Myoblast Proliferation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis	Activation Of MAPK Activity Protein O-linked Glycosylation O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process Hepatocyte Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways		Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling
Drugs		K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)
Protein-Protein Interactions		37 interactors: BAG1 CASP3 CBL CNR1 CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR FAS GAB1 GLMN GRB2 HGF HGS INPP5D INPPL1 ITGB4 MUC20 PCBD2 PIK3R1 PLCG1 PLXNB1 PTPN11 PTPRB PTPRJ RANBP10 RANBP9 SHC1 SMC1A SNAPIN SNX2 SPSB1 SRC STAT3 VAV1	3 interactors: ALDOB ELOVL3 MET
Entrez ID		4233	200958
HPRD ID		01280	17615
Ensembl ID		ENSG00000105976	ENSG00000176945
Uniprot IDs		B4DLF5 P08581
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4K3J
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Regulation Of Cell Activation Response To Growth Factor Developmental Process System Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Regulation Of Signal Transduction Multicellular Organismal Development Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Cell Communication Regulation Of Lymphocyte Activation Locomotion Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Phosphorylation Cell Differentiation Cell Motility Anatomical Structure Morphogenesis Neuron Differentiation Intracellular Signal Transduction Response To Organic Substance Neurogenesis Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Cell Migration Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of T Cell Activation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Response To Stimulus	Fructose Catabolic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Fructose 1,6-bisphosphate Metabolic Process Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Cofactor Metabolic Process Myoblast Proliferation Vacuolar Proton-transporting V-type ATPase Complex Assembly NADH Oxidation Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Very Long-chain Fatty Acid Biosynthetic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death Fatty Acid Elongation Endothelial Cell Morphogenesis Regulation Of Hydrogen Peroxide-induced Cell Death Monocarboxylic Acid Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Mesenchymal-epithelial Cell Signaling NADH Metabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis Fatty-acyl-CoA Biosynthetic Process Fructose Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Positive Chemotaxis Positive Regulation Of ATPase Activity Regulation Of Response To Reactive Oxygen Species Very Long-chain Fatty Acid Metabolic Process Regulation Of ATPase Activity Muscle Cell Migration Carboxylic Acid Metabolic Process Semaphorin-plexin Signaling Pathway Triglyceride Biosynthetic Process Endothelial Cell Development Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Glucose Transport NAD Metabolic Process Epithelial Cell Morphogenesis Organic Acid Metabolic Process Gluconeogenesis Positive Regulation Of Endothelial Cell Migration Myotube Differentiation Acyl-CoA Metabolic Process Hexose Biosynthetic Process Regulation Of Morphogenesis Of A Branching Structure Biosynthetic Process Endothelial Cell Differentiation
Tagcloud ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	associates attenuating augments branching cascade cdna docking gab1 grb2 hepatocyte hgf immunoglobulin met metalloproteinase morphogenesis mucin multifunctional nephropathy oligomerization oligomerize phosphatidylinositol pi3k preventing ras reduces require scattering terminus transient
Tagcloud (Difference) ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	associates attenuating augments branching cascade cdna docking gab1 grb2 hepatocyte hgf immunoglobulin met metalloproteinase morphogenesis mucin multifunctional nephropathy oligomerization oligomerize phosphatidylinositol pi3k preventing ras reduces require scattering terminus transient
Tagcloud (Intersection) ?