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MET and HGF
Number of citations of the paper that reports this interaction (PubMedID
18495663
)
52
Data Source:
HPRD
(in vivo, in vitro)
MET
HGF
Description
MET proto-oncogene, receptor tyrosine kinase
hepatocyte growth factor
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Basal Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Postsynapse
Extracellular Region
Extracellular Space
Membrane
Platelet Alpha Granule Lumen
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Hepatocyte Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Semaphorin Receptor Activity
Protein Phosphatase Binding
Identical Protein Binding
Molecular Function Activator Activity
Endopeptidase Activity
Serine-type Endopeptidase Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Activity
Chemoattractant Activity
Identical Protein Binding
Biological Process
Endothelial Cell Morphogenesis
Liver Development
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Neuron Differentiation
Pancreas Development
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Cell Development
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Positive Chemotaxis
Negative Regulation Of Stress Fiber Assembly
Excitatory Postsynaptic Potential
Establishment Of Skin Barrier
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Semaphorin-plexin Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Positive Regulation Of Endothelial Cell Chemotaxis
Mitotic Cell Cycle
Cell Morphogenesis
Epithelial To Mesenchymal Transition
Liver Development
Proteolysis
Signal Transduction
Negative Regulation Of Autophagy
Skeletal Muscle Cell Proliferation
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Cell Migration
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-10 Production
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Animal Organ Development
Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Chemotaxis
Regulation Of Multicellular Organismal Process
Myoblast Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of P38MAPK Cascade
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of DNA Biosynthetic Process
Pathways
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Drug-mediated inhibition of MET activation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Platelet degranulation
PIP3 activates AKT signaling
Interleukin-7 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
Drug-mediated inhibition of MET activation
Drugs
Sunitinib
K-252a
SGX-523
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
AMG-208
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
Crizotinib
Cabozantinib
Capmatinib
Tivozanib
Fostamatinib
Tivantinib
Brigatinib
Amuvatinib
Tepotinib
Amivantamab
Valproic acid
Heparin
O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
ABT-510
Foretinib
Diseases
Cholangiocarcinoma
Gastric cancer
Renal cell carcinoma
GWAS
Age at first sexual intercourse (
34211149
)
Alanine aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
HDL cholesterol levels (
28334899
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
28017375
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (beta blocking agents) (
31015401
)
Multiple sclerosis (severity) (
19010793
)
PR segment duration (
24850809
)
Pulse pressure (
30578418
)
Resting heart rate (
27798624
29769521
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Blood protein levels (
30072576
)
Endothelial growth factor levels (
25552591
)
Gestational age at birth (maternal effect) (
28598419
)
Gout (
22179738
)
Gout (normal type) (
32238385
)
Hepatocyte growth factor levels (
25998175
27989323
)
Intraocular pressure (
29235454
29785010
)
Rosacea symptom severity (
29771307
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Transverse temporal cortex volume (
31530798
)
Tuberculosis (
29036319
)
Interacting Genes
112 interacting genes:
ABL2
BAG1
BCAR3
BLK
BTK
CASP3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2B
CNR1
CRK
CTNNB1
CTTN
DAPK3
DCN
DNAJA3
EGFR
EPHA2
ERBB2
FAS
FES
FGFR4
FGR
FZR1
GAB1
GLIS2
GLMN
GRB14
GRB2
GRB7
HCK
HGF
HGS
HSH2D
INPP5D
INPPL1
ITGB1
ITGB4
ITK
KDELR2
LATS2
LCK
LYN
MAP2K3
MAP2K5
MATK
MUC20
MYC
NCK1
NCK2
NF2
PCBD2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PLXNB1
PTK6
PTPN11
PTPRB
PTPRJ
RAF1
RANBP10
RANBP9
RASA1
RASSF1
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA2
SMC1A
SNAPIN
SNX2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPSB1
SRC
STAP1
STAT3
STK11
SYK
TEC
TERT
TNS1
TNS2
TNS3
TNS4
TP53
TXK
VAV1
VAV2
VAV3
YES1
ZAP70
36 interacting genes:
ADAMTSL4
ARNT
BRCA1
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
CLEC3B
EPHA2
ERBB2
F11
FGFR4
FN1
GLIS2
HGFAC
HPN
KLKB1
LATS2
LCN2
MAP2K5
MAP2K6
MDM4
MEOX2
MET
NF2
PDGFRA
PLAU
RAF1
SDC1
SDC2
ST14
STK11
TEAD2
VTN
YWHAG
Entrez ID
4233
3082
HPRD ID
01280
00799
Ensembl ID
ENSG00000105976
ENSG00000019991
Uniprot IDs
B4DLF5
E6Y365
P08581
P14210
PDB IDs
1FYR
1R0P
1R1W
1SHY
1SSL
2G15
2RFN
2RFS
2UZX
2UZY
2WD1
2WGJ
2WKM
3A4P
3BUX
3C1X
3CCN
3CD8
3CE3
3CTH
3CTJ
3DKC
3DKF
3DKG
3EFJ
3EFK
3F66
3F82
3I5N
3L8V
3LQ8
3Q6U
3Q6W
3QTI
3R7O
3RHK
3U6H
3U6I
3VW8
3ZBX
3ZC5
3ZCL
3ZXZ
3ZZE
4AOI
4AP7
4DEG
4DEH
4DEI
4EEV
4GG5
4GG7
4IWD
4K3J
4KNB
4MXC
4O3T
4O3U
4R1V
4R1Y
4XMO
4XYF
5DG5
5EOB
5EYC
5EYD
5HLW
5HNI
5HO6
5HOA
5HOR
5HTI
5LSP
5T3Q
5UAB
5UAD
5YA5
6GCU
6I04
6SD9
6SDC
6SDD
6SDE
6UBW
6WVZ
7B3Q
7B3T
7B3V
7B3W
7B3Z
7B40
7B41
7B42
7B43
7B44
7MO7
7MO8
7MO9
7MOA
7MOB
7V3R
7V3S
7Y4T
7Y4U
8AN8
8ANS
8AU3
8AU5
8AW1
8GVJ
8K78
8OUU
8OUV
8OV7
8OVZ
8OW3
8OWG
9C1R
9IVB
1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4D3C
4K3J
4O3T
4O3U
5COE
5CP9
5CS1
5CS3
5CS5
5CS9
5CSQ
5CT1
5CT2
5CT3
7MO7
7MO8
7MO9
7MOA
7MOB
7OCL
7OCM
Enriched GO Terms of Interacting Partners
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Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Adhesion
Cytosol
ERBB Signaling Pathway
Immune Response-activating Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune System Process
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cell Activation
Peptidyl-tyrosine Phosphorylation
Leukocyte Activation
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Negative Regulation Of Signal Transduction
Protein Kinase Activity
Lymphocyte Activation
Activation Of Immune Response
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Immune System Process
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Immune System Process
Fc Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Regulation Of MAPK Cascade
T Cell Activation
Protein Kinase Activity
Negative Regulation Of Multicellular Organismal Process
Kinase Activity
Regulation Of Cell Population Proliferation
Protein Tyrosine Kinase Activity
Regulation Of Protein Metabolic Process
Signal Transduction
Cellular Developmental Process
Developmental Process
Cell Differentiation
Regulation Of Fibrinolysis
Animal Organ Development
Negative Regulation Of Blood Coagulation
Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Hemostasis
Transmembrane Receptor Protein Tyrosine Kinase Activity
Negative Regulation Of Coagulation
Regulation Of Multicellular Organismal Process
Serine-type Peptidase Activity
Regulation Of Signal Transduction
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Regulation Of Cellular Component Organization
Positive Regulation Of Protein Metabolic Process
Serine-type Endopeptidase Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Zymogen Activation
Positive Regulation Of Biosynthetic Process
Plasminogen Activation
Positive Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Maturation
Positive Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Adhesion
Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Regulation Of Cell Motility
Protein Metabolic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Plasminogen Activation
Regulation Of Cell-substrate Adhesion
Enzyme-linked Receptor Protein Signaling Pathway
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Tagcloud (Intersection)
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