MET and SPSB1

Number of citations of the paper that reports this interaction (PMID 15713673)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MET	SPSB1
Gene Name		MET proto-oncogene, receptor tyrosine kinase	splA/ryanodine receptor domain and SOCS box containing 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane	Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Phosphatase Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity Endothelial Cell Morphogenesis Liver Development Placenta Development Signal Transduction Cell Surface Receptor Signaling Pathway Axon Guidance Brain Development Skeletal Muscle Tissue Development Cell Proliferation Positive Regulation Of Glucose Transport Muscle Cell Migration Myotube Differentiation Peptidyl-tyrosine Phosphorylation Adult Behavior Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Myoblast Proliferation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)	Dental caries ( 23064961) Immune response to anthrax vaccine ( 22658931) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		37 interactors: BAG1 CASP3 CBL CNR1 CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR FAS GAB1 GLMN GRB2 HGF HGS INPP5D INPPL1 ITGB4 MUC20 PCBD2 PIK3R1 PLCG1 PLXNB1 PTPN11 PTPRB PTPRJ RANBP10 RANBP9 SHC1 SMC1A SNAPIN SNX2 SPSB1 SRC STAT3 VAV1	10 interactors: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1
Entrez ID		4233	80176
HPRD ID		01280	18106
Ensembl ID		ENSG00000105976	ENSG00000171621
Uniprot IDs		B4DLF5 P08581	Q96BD6
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4K3J	2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Regulation Of Cell Activation Response To Growth Factor Developmental Process System Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Regulation Of Signal Transduction Multicellular Organismal Development Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Cell Communication Regulation Of Lymphocyte Activation Locomotion Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Phosphorylation Cell Differentiation Cell Motility Anatomical Structure Morphogenesis Neuron Differentiation Intracellular Signal Transduction Response To Organic Substance Neurogenesis Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Cell Migration Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of T Cell Activation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Response To Stimulus	Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Chromatin Organization Peptidyl-arginine N-methylation Histone H4-R3 Methylation Histone Methylation Negative Regulation Of B Cell Proliferation Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Chromosome Organization Cell Development Protein Methylation Regulation Of RNA Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Immune System Process Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of B Cell Activation Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Regulation Of Cell Death Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Protein Metabolic Process Regulation Of B Cell Proliferation Regulation Of Organelle Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune System Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Leukocyte Proliferation Response To Stimulus Cellular Protein Metabolic Process
Tagcloud ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated
Tagcloud (Difference) ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated
Tagcloud (Intersection) ?