PLA2G4A and SHBG

Number of citations: 0 (PubMedID 15862967)
Data Source: BioGRID (two hybrid)

		PLA2G4A	SHBG
Name		phospholipase A2 group IVA	sex hormone binding globulin
Structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Extracellular Region Extracellular Exosome
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Lipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Hydrolase Activity Phosphatidylinositol-3-phosphate Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Carboxylic Ester Hydrolase Activity Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding	Steroid Binding Androgen Binding Protein Binding Lipid Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Monoacylglycerol Biosynthetic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Phospholipid Catabolic Process Positive Regulation Of Platelet Activation Lipid Catabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonate Secretion Establishment Of Localization In Cell Cellular Response To Antibiotic	None
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonate metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	None
Drugs		Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone	Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
GWAS		Blood urea nitrogen levels ( 31152163 ) Body size at age 10 ( 32376654 ) Crohn's disease ( 26192919 ) Estimated glomerular filtration rate ( 31152163 ) Generalized epilepsy ( 22949513 ) Hip circumference adjusted for BMI ( 28552196 ) Hyperinsulinemia in less-fat diet ( 30327367 ) Hyperinsulinemia x saturated fatty acids interaction ( 30327367 ) Inflammatory bowel disease ( 26192919 ) Knee osteoarthritis ( 18471798 ) Non-del(5q) myelodysplastic syndromes ( 31738830 ) Uterine fibroid size (maximum volume) ( 30196971 ) Zinc levels ( 26025379 )	A body shape index ( 34021172 ) Androgen levels ( 22936694 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Estradiol levels ( 34255042 ) Glycated hemoglobin levels ( 34059833 ) Heel bone mineral density ( 30598549 ) Hormone measurements ( 24049095 ) Medication use (calcium channel blockers) ( 31015401 ) Protein quantitative trait loci ( 18464913 ) Red cell distribution width ( 27863252 ) Refractive error ( 32231278 ) Sex hormone levels ( 26014426 ) Sex hormone-binding globulin levels ( 22675492 22829776 ) Testosterone levels ( 21998597 ) Uterine fibroids ( 31649266 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SPMIP6 SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		5321	6462
HPRD ID		08986	01646
Ensembl ID		ENSG00000116711	ENSG00000129214
Uniprot IDs		B4DZI4 P47712	B0FWH2 B0FWH8 I3L145 P04278
PDB IDs		1BCI 1CJY 1RLW	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
GO Terms Enriched among Interactors		Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Interleukin-18-mediated Signaling Pathway Response To Peptide Response To External Biotic Stimulus Response To Lipid Pyroptotic Inflammatory Response Response To Cytokine Protein Metabolic Process Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Response To Lipopolysaccharide Regulation Of Immune System Process Response To Muramyl Dipeptide Protein Kinase Activity Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Process Interleukin-1-mediated Signaling Pathway Response To Mechanical Stimulus Inflammatory Response Protein Serine Kinase Activity Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Protein Phosphorylation Regulation Of Cell Adhesion Phagolysosome Phosphorylation Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Negative Regulation Of Multicellular Organismal Process Protein Catabolic Process Cellular Response To Oxygen-containing Compound Kinase Activity Apoptotic Process Cellular Response To Cytokine Stimulus Focal Adhesion Negative Regulation Of Protein Catabolic Process Response To Tumor Necrosis Factor Programmed Cell Death Cell Death NLRP1 Inflammasome Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Calcium-dependent Protein Serine/threonine Kinase Activity Response To Nicotine Protein Modification Process Cellular Response To Lipid Stress-induced Premature Senescence	Extracellular Exosome Protease Binding Cell-cell Junction Fructose Biosynthetic Process Detoxification Of Copper Ion Extracellular Space Glucose 6-phosphate:phosphate Antiporter Activity Cellular Response To Cadmium Ion Lamellipodium Cellular Response To Zinc Ion Cellular Response To Copper Ion Mesenchyme Migration Glucose-6-phosphate Transport Negative Regulation Of Cardiac Muscle Contraction Intracellular Zinc Ion Homeostasis Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Copper Ion Rough Endoplasmic Reticulum Hexose Metabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Striated Muscle Contraction Response To Cadmium Ion Cell-cell Junction Organization Caveola Assembly Carbohydrate Metabolic Process Monosaccharide Metabolic Process Plasma Membrane Raft Assembly Response To Zinc Ion