PLA2G4A and C17orf59

Number of citations of the paper that reports this interaction (PMID 18330356)
4

Data Source:
BioGRID (two hybrid)

		PLA2G4A	C17orf59
Gene Name		phospholipase A2, group IVA (cytosolic, calcium-dependent)	chromosome 17 open reading frame 59
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic
Pathways		phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation
Drugs		Fluticasone Propionate Quinacrine Niflumic Acid
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E	5 interactors: EPS8 FBXO44 MOS PLA2G4A SHPRH
Entrez ID		5321	54785
HPRD ID		08986	13368
Ensembl ID		ENSG00000116711	ENSG00000196544
Uniprot IDs		E7EU42 P47712	Q96GS4
PDB IDs		1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction	Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Actin Polymerization-dependent Cell Motility Negative Regulation Of Meiotic Cell Cycle Phase Transition Platelet Activating Factor Biosynthetic Process Platelet Activating Factor Metabolic Process Establishment Of Meiotic Spindle Localization Exit From Mitosis Cardiolipin Acyl-chain Remodeling Behavioral Response To Ethanol Cardiolipin Metabolic Process Meiotic Spindle Organization Arachidonic Acid Secretion Phosphatidylinositol Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Rac Protein Signal Transduction Phosphatidylethanolamine Acyl-chain Remodeling Cellular Response To Antibiotic Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Phosphatidylcholine Acyl-chain Remodeling Cellular Response To Toxic Substance Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phospholipid Catabolic Process Phosphatidylserine Metabolic Process Negative Regulation Of Meiotic Cell Cycle Chromatin Organization Cellular Response To Stimulus Long-chain Fatty Acid Transport Regulation Of Meiosis Establishment Of Spindle Orientation Actin Filament Capping Icosanoid Biosynthetic Process Regulation Of Organelle Organization Organelle Organization Regulation Of Meiotic Cell Cycle Spindle Localization Phosphatidylcholine Metabolic Process Negative Regulation Of Actin Filament Depolymerization Response To Antibiotic Acid Secretion Fatty Acid Transport Chromosome Organization Actin Cytoskeleton Reorganization Cell Cycle Process Actin Filament Bundle Assembly Arachidonic Acid Metabolic Process
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?