PLA2G4A and PLA2G5

Number of citations of the paper that reports this interaction (PMID 12124392)
13

Data Source:
HPRD (in vitro)

		PLA2G4A	PLA2G5
Gene Name		phospholipase A2, group IVA (cytosolic, calcium-dependent)	phospholipase A2, group V
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle	Extracellular Region Golgi Apparatus Plasma Membrane Cell Surface Perinuclear Region Of Cytoplasm
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Calcium Ion Binding Heparin Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Lipid Catabolic Process Leukotriene Biosynthetic Process Response To Cytokine Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Response To CAMP
Pathways		phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation	Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs		Fluticasone Propionate Quinacrine Niflumic Acid
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E	1 interactors: PLA2G4A
Entrez ID		5321	5322
HPRD ID		08986	03117
Ensembl ID		ENSG00000116711
Uniprot IDs		E7EU42 P47712	P39877
PDB IDs		1BCI 1CJY 1RLW	2GHN
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction	Platelet Activating Factor Biosynthetic Process Platelet Activating Factor Metabolic Process Cardiolipin Acyl-chain Remodeling Cardiolipin Metabolic Process Arachidonic Acid Secretion Phosphatidylinositol Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Cellular Response To Antibiotic Phosphatidylethanolamine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Cellular Response To Toxic Substance Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phospholipid Catabolic Process Phosphatidylserine Metabolic Process Long-chain Fatty Acid Transport Icosanoid Biosynthetic Process Phosphatidylcholine Metabolic Process Response To Antibiotic Acid Secretion Fatty Acid Transport Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Cellular Biogenic Amine Metabolic Process Monocarboxylic Acid Transport Amine Metabolic Process Organophosphate Catabolic Process Cellular Lipid Catabolic Process Response To Toxic Substance Platelet Activation Glycerophospholipid Biosynthetic Process Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Lipid Catabolic Process Cellular Modified Amino Acid Metabolic Process Lipid Transport Glycerophospholipid Metabolic Process Carboxylic Acid Transport Organic Acid Transport Fatty Acid Metabolic Process Lipid Localization Alcohol Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Blood Coagulation Hemostasis Organic Anion Transport
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	a2s adds adipocytes adipose coordinators counteracting dysregulated facilitated hydrolyzed hyperlipidemia lipase lipolytic list m1 moderately obesity overladen palmitate phosphatidylcholine phosphatidylethanolamine phosphatidylserine phospholipase phospholipids polarization robustly spla2s tipped unsaturated
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	a2s adds adipocytes adipose coordinators counteracting dysregulated facilitated hydrolyzed hyperlipidemia lipase lipolytic list m1 moderately obesity overladen palmitate phosphatidylcholine phosphatidylethanolamine phosphatidylserine phospholipase phospholipids polarization robustly spla2s tipped unsaturated
Tagcloud (Intersection) ?