PLA2G4A and SIRT2

Number of citations of the paper that reports this interaction (PubMedID 26303530)
54

Data Source:
BioGRID (pull down)

		PLA2G4A	SIRT2
Description		phospholipase A2 group IVA	sirtuin 2
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Cell Projection Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Lipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Hydrolase Activity Phosphatidylinositol-3-phosphate Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Carboxylic Ester Hydrolase Activity Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding	Chromatin Binding NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Histone Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding Metal Ion Binding Histone H4K16 Deacetylase Activity, NAD-dependent NAD Binding NAD+ Binding DNA-binding Transcription Factor Binding NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Monoacylglycerol Biosynthetic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Phospholipid Catabolic Process Positive Regulation Of Platelet Activation Lipid Catabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonate Secretion Establishment Of Localization In Cell Cellular Response To Antibiotic	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Immune System Process Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Nervous System Development Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Skeletal Muscle Satellite Cell Differentiation Lipid Catabolic Process Substantia Nigra Development Myelination In Peripheral Nervous System Cell Differentiation Heterochromatin Formation Subtelomeric Heterochromatin Formation Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Post-translational Protein Modification NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Caloric Restriction Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonate metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	Initiation of Nuclear Envelope (NE) Reformation
Drugs		Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone	Cambinol
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	23 interacting genes: ARHGDIA ATRIP CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MCL1 MDM2 MORC2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1
Entrez ID		5321	22933
HPRD ID		08986	10377
Ensembl ID		ENSG00000116711	ENSG00000068903
Uniprot IDs		B4DZI4 P47712	A0A0A0MRF5 Q8IXJ6
PDB IDs		1BCI 1CJY 1RLW	1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6L71 6L72 6NR0 6QCN 7BOS 7BOT 8OWZ 8PY3 8QOO 8QT0 8QT1 8QT2 8QT3 8QT4 8QT8 8QTU 8TGP 8XE7
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Interleukin-18-mediated Signaling Pathway Response To Peptide Response To External Biotic Stimulus Response To Lipid Pyroptotic Inflammatory Response Response To Cytokine Protein Metabolic Process Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Response To Lipopolysaccharide Regulation Of Immune System Process Response To Muramyl Dipeptide Protein Kinase Activity Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Process Interleukin-1-mediated Signaling Pathway Response To Mechanical Stimulus Inflammatory Response Protein Serine Kinase Activity Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Protein Phosphorylation Regulation Of Cell Adhesion Phagolysosome Phosphorylation Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Negative Regulation Of Multicellular Organismal Process Protein Catabolic Process Cellular Response To Oxygen-containing Compound Kinase Activity Apoptotic Process Cellular Response To Cytokine Stimulus Focal Adhesion Negative Regulation Of Protein Catabolic Process Response To Tumor Necrosis Factor Programmed Cell Death Cell Death NLRP1 Inflammasome Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Calcium-dependent Protein Serine/threonine Kinase Activity Response To Nicotine Protein Modification Process Cellular Response To Lipid Stress-induced Premature Senescence	Regulation Of Cell Cycle Process Histone Deacetylase Binding Negative Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Cellular Response To Stress Negative Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation Nucleoplasm Protein-containing Complex Regulation Of Metabolic Process DNA Damage Response Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Peptidyl-lysine Acetylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Histone H3K9 Acetyltransferase Activity Acetyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Cellular Response To Stress Protein-lysine-acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis DNA Damage Checkpoint Signaling Histone Acetyltransferase Activity Nucleus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Protein Acetylation Chromatin Remodeling Small Molecule Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Monocarboxylic Acid Metabolic Process Epigenetic Regulation Of Gene Expression Cytosol Negative Regulation Of Centriole Replication Regulation Of Centrosome Duplication Intracellular Signal Transduction Response To Stress Gluconeogenesis Regulation Of Gluconeogenesis
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