PLA2G4A and CASP3

Number of citations of the paper that reports this interaction (PMID 9875225)
6

Data Source:
HPRD (in vitro)

		PLA2G4A	CASP3
Gene Name		phospholipase A2, group IVA (cytosolic, calcium-dependent)	caspase 3, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	B Cell Homeostasis Release Of Cytochrome C From Mitochondria Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Heart Development Sensory Perception Of Sound Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To UV Response To Wounding Extracellular Matrix Disassembly Neuron Differentiation Extracellular Matrix Organization Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Hippo Signaling T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation
Pathways		phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation	SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Cytochrome c-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Degradation of the extracellular matrix Role of DCC in regulating apoptosis Activation of caspases through apoptosome-mediated cleavage Activation of DNA fragmentation factor Apoptotic factor-mediated response Programmed Cell Death Intrinsic Pathway for Apoptosis Signalling by NGF Apoptotic cleavage of cellular proteins Cell death signalling via NRAGE, NRIF and NADE Apoptotic execution phase p75 NTR receptor-mediated signalling Stimulation of the cell death response by PAK-2p34 Apoptotic cleavage of cell adhesion proteins Signaling by Hippo Apoptosis induced DNA fragmentation Extrinsic Pathway NADE modulates death signalling
Drugs		Fluticasone Propionate Quinacrine Niflumic Acid	Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N\'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E	153 interactors: ACIN1 ADD1 AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SOCS5 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16
Entrez ID		5321	836
HPRD ID		08986	02799
Ensembl ID		ENSG00000116711	ENSG00000164305
Uniprot IDs		E7EU42 P47712	A8MVM1 P42574
PDB IDs		1BCI 1CJY 1RLW	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction	Cell Death Programmed Cell Death Apoptotic Process Death Regulation Of Cell Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Stimulus Regulation Of Catalytic Activity Response To Stress Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cell Death Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Proteolysis Cellular Response To Stress Immune System Process Multicellular Organismal Development Anatomical Structure Development Developmental Process Response To Organic Substance System Development Cell Differentiation Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Intersection) ?