PLA2G4A and XAGE1B

Number of citations: 0 (PubMedID 18330356)
Data Source: BioGRID (two hybrid)

		PLA2G4A	XAGE1B
Name		phospholipase A2 group IVA	X antigen family member 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	None
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Lipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Hydrolase Activity Phosphatidylinositol-3-phosphate Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Carboxylic Ester Hydrolase Activity Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding	Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Monoacylglycerol Biosynthetic Process Glycerophospholipid Metabolic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Phospholipid Catabolic Process Positive Regulation Of Platelet Activation Lipid Catabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonate Secretion Establishment Of Localization In Cell Cellular Response To Antibiotic	None
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonate metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	None
Drugs		Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone	None
GWAS		Blood urea nitrogen levels ( 31152163 ) Body size at age 10 ( 32376654 ) Crohn's disease ( 26192919 ) Estimated glomerular filtration rate ( 31152163 ) Generalized epilepsy ( 22949513 ) Hip circumference adjusted for BMI ( 28552196 ) Hyperinsulinemia in less-fat diet ( 30327367 ) Hyperinsulinemia x saturated fatty acids interaction ( 30327367 ) Inflammatory bowel disease ( 26192919 ) Knee osteoarthritis ( 18471798 ) Non-del(5q) myelodysplastic syndromes ( 31738830 ) Uterine fibroid size (maximum volume) ( 30196971 ) Zinc levels ( 26025379 )	No GWAS studies recorded
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	10 interacting genes: BANP PAXIP1 PLA2G4A RYBP SETBP1 TRIM55 TRIM63 TSPYL2 YAF2 YY1
Entrez ID		5321	653067
HPRD ID		08986	19219
Ensembl ID		ENSG00000116711	ENSG00000204382
Uniprot IDs		B4DZI4 P47712	Q9HD64
PDB IDs		1BCI 1CJY 1RLW	Not available
GO Terms Enriched among Interactors		Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Defense Response Interleukin-18-mediated Signaling Pathway Response To Peptide Response To External Biotic Stimulus Response To Lipid Pyroptotic Inflammatory Response Response To Cytokine Protein Metabolic Process Regulation Of Inflammatory Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Response To Lipopolysaccharide Regulation Of Immune System Process Response To Muramyl Dipeptide Protein Kinase Activity Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Regulation Of Multicellular Organismal Process Interleukin-1-mediated Signaling Pathway Response To Mechanical Stimulus Inflammatory Response Protein Serine Kinase Activity Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Protein Phosphorylation Regulation Of Cell Adhesion Phagolysosome Phosphorylation Canonical Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Negative Regulation Of Multicellular Organismal Process Protein Catabolic Process Cellular Response To Oxygen-containing Compound Kinase Activity Apoptotic Process Cellular Response To Cytokine Stimulus Focal Adhesion Negative Regulation Of Protein Catabolic Process Response To Tumor Necrosis Factor Programmed Cell Death Cell Death NLRP1 Inflammasome Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Calcium-dependent Protein Serine/threonine Kinase Activity Response To Nicotine Protein Modification Process Cellular Response To Lipid Stress-induced Premature Senescence	Chromatin Organization Chromatin Remodeling Nucleus PcG Protein Complex Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Phosphatidylglycerol Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Cardiac Muscle Hypertrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation