PLA2G4A and CAP1

Number of citations of the paper that reports this interaction (PMID 18330356)
4

Data Source:
BioGRID (two hybrid)

		PLA2G4A	CAP1
Gene Name		phospholipase A2, group IVA (cytosolic, calcium-dependent)	CAP, adenylate cyclase-associated protein 1 (yeast)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle	Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Actin Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	Ameboidal-type Cell Migration Platelet Degranulation Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity Axon Guidance Blood Coagulation Actin Cytoskeleton Organization Platelet Activation
Pathways		phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation	Role of Abl in Robo-Slit signaling Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Signaling by Robo receptor
Drugs		Fluticasone Propionate Quinacrine Niflumic Acid
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E	9 interactors: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5
Entrez ID		5321	10487
HPRD ID		08986	09869
Ensembl ID		ENSG00000116711	ENSG00000131236
Uniprot IDs		E7EU42 P47712	D3DPU2 Q01518
PDB IDs		1BCI 1CJY 1RLW	1K8F
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction	Tissue Homeostasis Platelet Activation Nervous System Development Cell Activation Multicellular Organismal Homeostasis Platelet Aggregation Generation Of Neurons Neuron Projection Development Neurogenesis Homotypic Cell-cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Retina Homeostasis Cellular Response To Stimulus Cell Development Neuron Development Axon Guidance ERBB2-ERBB3 Signaling Pathway DNA Ligation Involved In DNA Recombination Skeletal Muscle Hypertrophy Blood Coagulation Hemostasis Midbrain Development Adherens Junction Organization Neuron Differentiation Response To Stress Cell Projection Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB2 Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Single Organismal Cell-cell Adhesion Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation DNA Repair Wound Healing Chemotaxis Response To Stimulus Neuron Projection Morphogenesis Platelet Activating Factor Biosynthetic Process System Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activating Factor Metabolic Process Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases	alarco albicans balan brefeldin bzip caglr1 cai4 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants yap1
Tagcloud (Intersection) ?