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PFDN2 and MAP3K3
Number of citations of the paper that reports this interaction (PMID
14743216
)
197
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
PFDN2
MAP3K3
Gene Name
prefoldin subunit 2
mitogen-activated protein kinase kinase kinase 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Prefoldin Complex
Extracellular Vesicular Exosome
Intracellular
Cytosol
Molecular Function
Protein Binding
Unfolded Protein Binding
Protein Kinase Activity
MAP Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Protein Folding
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Blood Vessel Development
Intracellular Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Autophosphorylation
Positive Regulation Of P38MAPK Cascade
Pathways
Protein folding
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Chaperonin-mediated protein folding
Signaling by Interleukins
Cytokine Signaling in Immune system
Interleukin-1 signaling
Drugs
Diseases
GWAS
Height (
21998595
22021425
18391951
)
Protein-Protein Interactions
5 interactors:
MAP3K3
PFDN1
PFDN4
SNCA
VBP1
44 interactors:
BIRC2
BRCA1
CDC37
COPS5
GAB1
GLRX3
GTF2I
HSP90AA1
HSP90AB1
HSPA2
IKBKB
MAP2K3
MAP2K4
MAP2K5
MAP2K7
MAP3K2
MAP3K5
MAP3K7
MARK2
MBP
NEDD4
NEDD4L
NFKBIA
PFDN2
PRKACA
RCAN1
RIPK1
SMURF1
SPAG9
SQSTM1
TOM1L1
TRAF6
TRAF7
UBC
VWF
WNK1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZBTB16
Entrez ID
5202
4215
HPRD ID
09658
03965
Ensembl ID
ENSG00000143256
ENSG00000198909
Uniprot IDs
B1AQP2
Q9UHV9
J3KRN4
J3QRB6
Q99759
PDB IDs
2C60
2JRH
2O2V
2PPH
Enriched GO Terms of Interacting Partners
?
'de Novo' Posttranslational Protein Folding
'de Novo' Protein Folding
Protein Folding
Negative Regulation Of Thrombin Receptor Signaling Pathway
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Norepinephrine Uptake
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Positive Regulation Of Glutathione Peroxidase Activity
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Negative Regulation Of Dopamine Metabolic Process
Negative Regulation Of Cellular Respiration
Protein Metabolic Process
Negative Regulation Of Oxidative Phosphorylation
Negative Regulation Of Synaptic Transmission, Dopaminergic
Response To Iron(II) Ion
Cellular Response To Copper Ion
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Synaptic Vesicle Recycling
Positive Regulation Of P38MAPK Cascade
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Regulation Of Oxidative Phosphorylation
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Regulation Of Hydrogen Peroxide Metabolic Process
Dopamine Transport
Regulation Of Glutamate Secretion
Dopamine Biosynthetic Process
Negative Regulation Of Monooxygenase Activity
Neurotransmitter Uptake
Regulation Of Cellular Respiration
Microglial Cell Activation
Extracellular Fibril Organization
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Synaptic Transmission, Dopaminergic
Behavioral Response To Cocaine
Regulation Of Neurotransmitter Uptake
Negative Regulation Of Microtubule Polymerization
Regulation Of P38MAPK Cascade
Positive Regulation Of Neurotransmitter Secretion
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Acyl-CoA Biosynthetic Process
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Receptor Recycling
Positive Regulation Of Protein Kinase Activity
Catecholamine Biosynthetic Process
Regulation Of Synaptic Transmission, Dopaminergic
Response To Epinephrine
Regulation Of Dopamine Metabolic Process
Leukocyte Activation
Positive Regulation Of Protein Metabolic Process
Activation Of Protein Kinase Activity
Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Intracellular Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transferase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Apoptotic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Programmed Cell Death
Cell Death
Positive Regulation Of Protein Serine/threonine Kinase Activity
Death
Regulation Of Apoptotic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Phosphorylation
Regulation Of Cell Death
Activation Of MAPK Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Catalytic Activity
MAPK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
JNK Cascade
Signaling
Response To Stress
Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cell Communication
Signal Transduction By Phosphorylation
Positive Regulation Of MAP Kinase Activity
Regulation Of MAP Kinase Activity
Tagcloud
?
11ra
affymetrix
cacna1s
classify
correctly
dataset
erosive
favors
flammatory
ikbkb
nucleoporin
partitioning
paxgene
pbc
pbcs
proin
psa
psoriatic
psors1
psors2
recursive
s100a12
s100a8
shp1
sigirr
tcf7
thioredoxin
tubes
u133a
Tagcloud (Difference)
?
11ra
affymetrix
cacna1s
classify
correctly
dataset
erosive
favors
flammatory
ikbkb
nucleoporin
partitioning
paxgene
pbc
pbcs
proin
psa
psoriatic
psors1
psors2
recursive
s100a12
s100a8
shp1
sigirr
tcf7
thioredoxin
tubes
u133a
Tagcloud (Intersection)
?