PFDN2 and PFDN1

Number of citations: 0 (PubMedID 14634002)
Data Source: HPRD (in vitro)

		PFDN2	PFDN1
Name		prefoldin subunit 2	prefoldin subunit 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Folding Protein Stabilization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Prefoldin mediated transfer of substrate to CCT/TriC
GWAS		No GWAS studies recorded	Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Reaction time ( 29844566 )
Interacting Genes		10 interacting genes: CEBPA DBI ERBB3 MAP3K3 PFDN1 PFDN4 PKNOX1 UBASH3A VBP1 ZNF726	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		5202	5201
HPRD ID		09658	05357
Ensembl ID		ENSG00000143256	ENSG00000113068
Uniprot IDs		B1AQP2 Q9UHV9	O60925
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
GO Terms Enriched among Interactors		Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid-beta Binding Unfolded Protein Binding Protein-containing Complex Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Protein Folding Negative Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Protein-lipid Complex Negative Regulation Of Protein Lipidation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Protein Metabolic Process CHOP-C/EBP Complex Regulation Of Metabolic Process Neuregulin Receptor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Negative Regulation Of Lipoprotein Metabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Dorsal Root Ganglion Development	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization