PFDN2 and PFDN4

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical, biochemical)
HPRD (in vitro)

		PFDN2	PFDN4
Gene Name		prefoldin subunit 2	prefoldin subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Prefoldin Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex
	Molecular Function	Protein Binding Unfolded Protein Binding	Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding	Protein Folding Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs
Diseases
GWAS			Atopic dermatitis ( 23042114) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: MAP3K3 PFDN1 PFDN4 SNCA VBP1	5 interactors: ACTB PFDN2 TUBA4A TUBB VBP1
Entrez ID		5202	5203
HPRD ID		09658	05358
Ensembl ID		ENSG00000143256	ENSG00000101132
Uniprot IDs		B1AQP2 Q9UHV9	Q9NQP4
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Protein Metabolic Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Iron(II) Ion Cellular Response To Copper Ion Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Recycling Positive Regulation Of P38MAPK Cascade Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Negative Regulation Of Microtubule Polymerization Regulation Of P38MAPK Cascade Positive Regulation Of Neurotransmitter Secretion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Acyl-CoA Biosynthetic Process Cellular Response To Epinephrine Stimulus Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Kinase Activity Catecholamine Biosynthetic Process Regulation Of Synaptic Transmission, Dopaminergic Response To Epinephrine Regulation Of Dopamine Metabolic Process Leukocyte Activation	'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Platelet Activation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Complex Assembly Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Cellular Component Assembly Cellular Protein Metabolic Process Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Body Fluid Levels Wound Healing Cellular Macromolecular Complex Assembly Leukocyte Mediated Cytotoxicity Mitotic Cell Cycle Process Cell Activation Substantia Nigra Development Response To Wounding Platelet Aggregation Cellular Response To Interleukin-4 Mitotic Cell Cycle Microtubule-based Process Response To Interleukin-4 Innate Immune Response Neural Nucleus Development Protein Metabolic Process Retina Homeostasis
Tagcloud ?			12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated
Tagcloud (Difference) ?			12p11 13q11 16q24 1p32 20q13 3q21 bacs cdkn1b cgh chromosomes copy cyp24 fstl1 heterozygosity hyperplastic informative loh16 loh9 narrowed overcomes p13 ppp2r3 q25 q32 rip stmn1 sv40 syntenic unappreciated
Tagcloud (Intersection) ?