MYPOP and TGM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYPOP	TGM1
Description		Myb related transcription factor, partner of profilin	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways			Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Asthma ( 31959851)
Interacting Genes		42 interacting genes: AKAP8L BAG4 BBC3 CARD10 CHIC2 CIB4 CYSRT1 FHL3 HNRNPH1 HNRNPK HOXA1 KHDRBS3 KIFAP3 KRT40 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP5-6 MDFI MTUS2 NBPF19 NCK2 NECAB2 NOTCH2NLA PFN1 PFN2 PRDM14 PRR3 RBM3 RBMX RBMY1A1 RBPMS2 SAT1 SYNCRIP TGM1 TNS2 TRA2B	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		339344	7051
HPRD ID		17352	01824
Ensembl ID		ENSG00000176182	ENSG00000092295
Uniprot IDs		Q86VE0	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Keratin Filament Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Positive Regulation Of Actin Filament Polymerization RNA Binding Nucleic Acid Binding MRNA Processing Identical Protein Binding RNA Splicing MRNA Binding Positive Regulation Of Protein Polymerization Catalytic Step 2 Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Protein-containing Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing Regulation Of Actin Filament Polymerization Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of MRNA Metabolic Process Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Actin Filament Bundle Assembly Protein Binding Adenyl-nucleotide Exchange Factor Activity Positive Regulation Of Supramolecular Fiber Organization Modification Of Postsynaptic Structure Positive Regulation Of Cytoskeleton Organization Negative Regulation Of MRNA Splicing, Via Spliceosome Modification Of Synaptic Structure Actin Monomer Binding Regulation Of Stress Fiber Assembly Ribonucleoprotein Complex Protein Domain Specific Binding Negative Regulation Of RNA Splicing Semicircular Canal Formation Spermidine Binding Negative Regulation Of MRNA Modification T Cell Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity
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