DNM1 and AMPH

Number of citations of the paper that reports this interaction (PubMedID 9348539)
37

Data Source:
HPRD (in vitro)

		DNM1	AMPH
Description		dynamin 1	amphiphysin
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GO Annotations	Cellular Component	Cytoplasm Microtubule Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Cytoplasmic Vesicle Chromaffin Granule Cell Projection Synapse Extracellular Exosome Presynapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Synaptic Vesicle Membrane Leading Edge Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Hydrolase Activity GDP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Phospholipid Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Homooligomerization Protein Homotetramerization Regulation Of Vesicle Size Clathrin Coat Assembly Involved In Endocytosis Vesicle Scission	Endocytosis Chemical Synaptic Transmission Synaptic Vesicle Endocytosis
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)	Ankylosing spondylitis ( 30946743) Bitter non-alcoholic beverage consumption ( 31046077) Cerebral microbleeds ( 31209788) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		53 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNMBP DYRK1A EPS15 FILNC1 FNBP1 FTCD GRB2 GRIN1 GRIN2D HSPA13 ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PCNT PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PLK2 PRKCA PRNP RACK1 RNF10 SH3GL1 SH3GL2 SH3GL3 SNAP25 SNCA SNX9 SRC SUMO1 TIMM50 UBE2I	29 interacting genes: AP2A2 ARL16 BIN1 CABIN1 CDK1 CDK5 CDK5R1 CLTC DEUP1 DNM1 DNM2 DYRK1A EGFR ITSN2 KHDRBS1 LGMN MAPK6 MAPT NECAP1 PLD2 PPP3CA PPP3CC SH3GL2 SH3GLB1 SYN1 SYNJ1 TERF1 UBC VTN
Entrez ID		1759	273
HPRD ID		03851	02687
Ensembl ID		ENSG00000106976	ENSG00000078053
Uniprot IDs		A0A994J7J4 B4DK06 B7ZAC0 Q05193	P49418
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A 7AX3 8SXZ 8SZ4 8SZ7 8SZ8 8T0K 8T0R 8TYM 8TYN	1KY7 1UTC 3SOG 4ATM 5M5S 5M61
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Presynaptic Endocytosis Glutamatergic Synapse Cytoplasm Lipid Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Cellular Component Biogenesis Cytosol Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Polymerization Perinuclear Region Of Cytoplasm Presynapse Cellular Component Assembly Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Plasma Membrane Plasma Membrane Tubulation Clathrin-coated Pit Phospholipid Binding Regulation Of Actin Filament Polymerization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Regulation Of Synaptic Plasticity Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Regulation Of Calcium Ion Transport Cadherin Binding Neurotrophin TRKA Receptor Binding Regulation Of Cytoskeleton Organization Synapse Negative Regulation Of Transport Long-term Synaptic Potentiation Regulation Of Signaling Regulation Of Apoptotic Process	Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Presynapse Synaptic Vesicle Endocytosis Endocytosis Import Into Cell Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Pit Receptor-mediated Endocytosis Establishment Of Localization In Cell Tau Protein Binding Vesicle Scission Regulation Of Vesicle-mediated Transport Receptor Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Negative Regulation Of Macromolecule Metabolic Process Protein Kinase 5 Complex Protein Polymerization Protein Kinase Binding Positive Regulation Of Cellular Component Organization Cytosol Regulation Of Developmental Growth Negative Regulation Of Metabolic Process Identical Protein Binding Clathrin-dependent Endocytosis Positive Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Assembly Microtubule Negative Regulation Of ERBB Signaling Pathway Clathrin Coat Disassembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Calmodulin-dependent Protein Phosphatase Activity Synaptic Vesicle Transport Negative Regulation Of Calcium Ion Transmembrane Transport Vesicle Uncoating Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of DNA Replication Axon Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Vesicle Localization Clathrin Coat Of Coated Pit Regulation Of Growth Membrane Fission Cell Projection Organization Cytoplasmic Vesicle
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