DNM1 and CLIC3

Number of citations of the paper that reports this interaction (PubMedID 11563969)
53

Data Source:
HPRD (in vitro)

		DNM1	CLIC3
Description		dynamin 1	chloride intracellular channel 3
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GO Annotations	Cellular Component	Cytoplasm Microtubule Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Cytoplasmic Vesicle Chromaffin Granule Cell Projection Synapse Extracellular Exosome Presynapse	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Body Extracellular Matrix Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Hydrolase Activity GDP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity	Chloride Channel Activity Protein Binding Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Homooligomerization Protein Homotetramerization Regulation Of Vesicle Size Clathrin Coat Assembly Involved In Endocytosis Vesicle Scission	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sprouting Angiogenesis
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)
Interacting Genes		53 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNMBP DYRK1A EPS15 FILNC1 FNBP1 FTCD GRB2 GRIN1 GRIN2D HSPA13 ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PCNT PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PLK2 PRKCA PRNP RACK1 RNF10 SH3GL1 SH3GL2 SH3GL3 SNAP25 SNCA SNX9 SRC SUMO1 TIMM50 UBE2I	35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP CIMIP2B DDIT4L DNM1 EFHC2 GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 SPMIP4 SPMIP6 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620
Entrez ID		1759	9022
HPRD ID		03851	05941
Ensembl ID		ENSG00000106976	ENSG00000169583
Uniprot IDs		A0A994J7J4 B4DK06 B7ZAC0 Q05193	O95833
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A 7AX3 8SXZ 8SZ4 8SZ7 8SZ8 8T0K 8T0R 8TYM 8TYN	3FY7 3KJY
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Presynaptic Endocytosis Glutamatergic Synapse Cytoplasm Lipid Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Cellular Component Biogenesis Cytosol Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Polymerization Perinuclear Region Of Cytoplasm Presynapse Cellular Component Assembly Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Plasma Membrane Plasma Membrane Tubulation Clathrin-coated Pit Phospholipid Binding Regulation Of Actin Filament Polymerization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Regulation Of Synaptic Plasticity Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Regulation Of Calcium Ion Transport Cadherin Binding Neurotrophin TRKA Receptor Binding Regulation Of Cytoskeleton Organization Synapse Negative Regulation Of Transport Long-term Synaptic Potentiation Regulation Of Signaling Regulation Of Apoptotic Process
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