DNM1 and TIMM50

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		DNM1	TIMM50
Gene Name		dynamin 1	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Microtubule Plasma Membrane Membrane Coat Extracellular Vesicular Exosome	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane Nuclear Speck
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding Protein Kinase Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding Nitric-oxide Synthase Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Axon Guidance Receptor Internalization Ephrin Receptor Signaling Pathway Clathrin-mediated Endocytosis	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Protein Targeting To Mitochondrion Mitochondrial Membrane Organization Peptidyl-tyrosine Dephosphorylation Cellular Protein Metabolic Process
Pathways		Retrograde neurotrophin signalling Signalling by NGF Formation of annular gap junctions Axon guidance Gap junction degradation Gap junction trafficking L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades EPH-ephrin mediated repulsion of cells Toll Like Receptor 4 (TLR4) Cascade Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Adaptive Immune System Innate Immune System	Mitochondrial protein import
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		47 interactors: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GNB2L1 GRB2 GRIN1 GRIN2D ITSN1 KIAA1377 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I	4 interactors: DNM1 PAFAH1B2 RAF1 TNFRSF10B
Entrez ID		1759	92609
HPRD ID		03851	12118
Ensembl ID		ENSG00000106976	ENSG00000105197
Uniprot IDs		Q05193	Q3ZCQ8
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Protein Complex Assembly Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cellular Component Assembly Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Membrane Organization Transport Axon Guidance Cell Projection Organization Regulation Of Signaling Neuron Projection Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Synaptic Vesicle Transport Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Neuron Development Generation Of Neurons Membrane Tubulation Signaling Axonogenesis Anatomical Structure Development Protein Complex Assembly Neurogenesis Cell Communication Anatomical Structure Morphogenesis Locomotion Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Cell Morphogenesis Involved In Differentiation Axon Development Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Recycling Regulation Of Signal Transduction Neurotrophin Signaling Pathway Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Positive Regulation Of Metabolic Process Neuron Differentiation Negative Regulation Of Endocytosis	Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Protein Kinase Activity Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Axon Guidance Response To External Stimulus Regulation Of Peptidase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Macroautophagy Axonogenesis Positive Regulation Of Transferase Activity Axon Development Nervous System Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Activation Of Adenylate Cyclase Activity Activation Of NF-kappaB-inducing Kinase Activity Endosome Organization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Autophagy Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Clathrin-mediated Endocytosis Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Intermediate Filament Cytoskeleton Organization NIK/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NIK/NF-kappaB Signaling Cell Projection Morphogenesis Intermediate Filament-based Process Receptor Internalization Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?