CXCL14 and GPR85

Number of citations of the paper that reports this interaction (PubMedID 30204129)
64

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CXCL14	GPR85
Description		C-X-C motif chemokine ligand 14	G protein-coupled receptor 85
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Triglycerides ( 25961943)
Interacting Genes		28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1	1 interacting genes: CXCL14
Entrez ID		9547	54329
HPRD ID		16049	05543
Ensembl ID		ENSG00000145824	ENSG00000164604
Uniprot IDs		O95715	A4D0T8 P60893 Q8NEN2
PDB IDs		2HDL
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Leukocyte Chemotaxis Locomotion Cell Chemotaxis Humoral Immune Response Cytokine Activity Granulocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Leukocyte Migration Myeloid Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Response To External Biotic Stimulus Response To Other Organism Immune System Process Defense Response Immune Response Inflammatory Response CXCR Chemokine Receptor Binding Chemokine-mediated Signaling Pathway Cell Killing Cell Migration Cell Motility Mononuclear Cell Migration Chemokine Receptor Binding Neutrophil Chemotaxis CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Extracellular Space Response To Stress Neutrophil Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway CXCR3 Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Eosinophil Chemotaxis Extracellular Region Positive Regulation Of Leukocyte Chemotaxis Regulation Of T Cell Migration Positive Regulation Of Mononuclear Cell Migration Eosinophil Migration Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis	Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Putamen Development Caudate Nucleus Development Membrane Depolarization During AV Node Cell Action Potential Epithelial Cell Proliferation Involved In Lung Morphogenesis Photoreceptor Ribbon Synapse Righting Reflex Vocal Learning Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Observational Learning Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis L-type Voltage-gated Calcium Channel Complex Cerebellar Purkinje Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration High Voltage-gated Calcium Channel Activity Auditory Behavior Membrane Depolarization During Cardiac Muscle Cell Action Potential Mechanosensory Behavior Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Cell-cell Signaling Membrane Depolarization During Action Potential Reflex Cell Differentiation In Hindbrain Vocalization Behavior Smooth Muscle Tissue Development Signaling Cell Communication Voltage-gated Calcium Channel Complex Positive Regulation Of Mesenchymal Cell Proliferation Voltage-gated Calcium Channel Activity Calcium Ion Import Regulation Of Mesenchymal Cell Proliferation Neuromuscular Junction Development Regulation Of Heart Rate By Cardiac Conduction Transcription Coregulator Binding Nervous System Process Positive Regulation Of Muscle Contraction Cardiac Conduction Chemokine Activity Lung Alveolus Development Membrane Depolarization Cerebellum Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport
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