CXCL14 and JMJD6

Number of citations of the paper that reports this interaction (PubMedID 30204129)
64

Data Source:
BioGRID (pull down)

		CXCL14	JMJD6
Description		C-X-C motif chemokine ligand 14	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways			HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1	30 interacting genes: AEBP2 ANKEF1 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		9547	23210
HPRD ID		16049	05371
Ensembl ID		ENSG00000145824	ENSG00000070495
Uniprot IDs		O95715	B2WTI3 B2WTI4 Q6NYC1
PDB IDs		2HDL	3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Leukocyte Chemotaxis Locomotion Cell Chemotaxis Humoral Immune Response Cytokine Activity Granulocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Leukocyte Migration Myeloid Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Response To External Biotic Stimulus Response To Other Organism Immune System Process Defense Response Immune Response Inflammatory Response CXCR Chemokine Receptor Binding Chemokine-mediated Signaling Pathway Cell Killing Cell Migration Cell Motility Mononuclear Cell Migration Chemokine Receptor Binding Neutrophil Chemotaxis CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Extracellular Space Response To Stress Neutrophil Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway CXCR3 Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Eosinophil Chemotaxis Extracellular Region Positive Regulation Of Leukocyte Chemotaxis Regulation Of T Cell Migration Positive Regulation Of Mononuclear Cell Migration Eosinophil Migration Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis	Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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