CXCL14 and ROBO3

Number of citations of the paper that reports this interaction (PubMedID 30204129)
64

Data Source:
BioGRID (pull down)

		CXCL14	ROBO3
Description		C-X-C motif chemokine ligand 14	roundabout guidance receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Plasma Membrane Membrane Axon
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Neuron Migration Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Axon Midline Choice Point Recognition Cell Differentiation Tube Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Dendrite Self-avoidance Commissural Neuron Axon Guidance Positive Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)	Macular thickness ( 30535121)
Interacting Genes		28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1	9 interacting genes: APP CCDC57 CXCL14 HSF2BP LNX1 MTUS2 NEDD4L PICK1 RBMX
Entrez ID		9547	64221
HPRD ID		16049	10554
Ensembl ID		ENSG00000145824	ENSG00000154134
Uniprot IDs		O95715	Q96MS0
PDB IDs		2HDL	6POG 6POK 6POL
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Leukocyte Chemotaxis Locomotion Cell Chemotaxis Humoral Immune Response Cytokine Activity Granulocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Leukocyte Migration Myeloid Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Response To External Biotic Stimulus Response To Other Organism Immune System Process Defense Response Immune Response Inflammatory Response CXCR Chemokine Receptor Binding Chemokine-mediated Signaling Pathway Cell Killing Cell Migration Cell Motility Mononuclear Cell Migration Chemokine Receptor Binding Neutrophil Chemotaxis CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Extracellular Space Response To Stress Neutrophil Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway CXCR3 Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Eosinophil Chemotaxis Extracellular Region Positive Regulation Of Leukocyte Chemotaxis Regulation Of T Cell Migration Positive Regulation Of Mononuclear Cell Migration Eosinophil Migration Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis	Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Glial Cell Development Synapse Organization Regulation Of Endocytosis Plasma Membrane Bounded Cell Projection Organization G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Cell Junction Organization Cell Projection Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Membrane Curvature Sensor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Supraspliceosomal Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Main Axon Regulation Of Spontaneous Synaptic Transmission
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