CCL13 and XCL1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL13	XCL1
Description		C-C motif chemokine ligand 13	X-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Psoriasis ( 34927100)
Interacting Genes		26 interacting genes: ACKR2 ACKR4 APP CCL11 CCL2 CCL21 CCL24 CCL26 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 HNRNPH3 MMP1 MMP3 NOD2 PF4 PPBP XCL1	19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1
Entrez ID		6357	6375
HPRD ID		03230	02595
Ensembl ID		ENSG00000181374	ENSG00000143184
Uniprot IDs		Q99616	P47992
PDB IDs		2RA4	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Chemokine Activity Locomotion Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Leukocyte Migration Myeloid Leukocyte Migration Humoral Immune Response Immune Response Granulocyte Chemotaxis Cytokine Activity Cell Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Cell Motility Immune System Process Defense Response Inflammatory Response Defense Response To Symbiont Mononuclear Cell Migration Defense Response To Other Organism G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Cell Killing Response To External Biotic Stimulus Response To Other Organism Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Chemotaxis Extracellular Space Response To Stress CXCR Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Extracellular Region Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Motility Chemokine Receptor Binding Positive Regulation Of Locomotion Cell-cell Signaling Positive Regulation Of Calcium Ion Transport	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication
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