CCL13 and ACKR2

Number of citations of the paper that reports this interaction (PMID 9405404)
30

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CCL13	ACKR2
Gene Name		chemokine (C-C motif) ligand 13	atypical chemokine receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Receptor Binding Chemokine Activity	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Eosinophil Chemotaxis	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: ACKR2 ACKR4 APP CCR3 CCR5 HNRNPH3 MMP1 MMP3	16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8
Entrez ID		6357	1238
HPRD ID		03230	09095
Ensembl ID		ENSG00000181374	ENSG00000144648
Uniprot IDs		Q99616	O00590
PDB IDs		2RA4
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Oligomerization Cellular Response To Cytokine Stimulus Regulation Of Protein Oligomerization Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To External Stimulus Cellular Response To Organic Substance Cellular Defense Response Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Response To Stress Cellular Metal Ion Homeostasis Immune System Process Inflammatory Response Collagen Metabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Multicellular Organismal Macromolecule Metabolic Process Cellular Ion Homeostasis Multicellular Organismal Metabolic Process Metal Ion Homeostasis Extracellular Matrix Disassembly Immune Response Response To Organic Substance Cellular Chemical Homeostasis Defense Response Viral Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Collateral Sprouting In Absence Of Injury Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Surface Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Cytosolic Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death	Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis
Tagcloud ?		3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Difference) ?		3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Intersection) ?