RPS6KA1 and BAD

Number of citations of the paper that reports this interaction (PubMedID 12897128)
42

Data Source:
HPRD (in vitro, in vivo)

		RPS6KA1	BAD
Description		ribosomal protein S6 kinase A1	BCL2 associated agonist of cell death
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Purvalanol A Fostamatinib	Navitoclax
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)	Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB	46 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6195	572
HPRD ID		03402	04409
Ensembl ID		ENSG00000117676	ENSG00000002330
Uniprot IDs		Q15418	Q92934
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV	1G5J 7Q16
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway
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