RPS6KA1 and GRID2IP

Number of citations of the paper that reports this interaction (PubMedID 30726710)
43

Data Source:
BioGRID (unspecified method)

		RPS6KA1	GRID2IP
Description		ribosomal protein S6 kinase A1	Grid2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse	Plasma Membrane Membrane Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Long-term Synaptic Depression Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Purvalanol A Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)	Body mass index ( 26426971) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Ulcerative colitis ( 28067908)
Interacting Genes		88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB	2 interacting genes: GRID2 RPS6KA1
Entrez ID		6195	392862
HPRD ID		03402	19587
Ensembl ID		ENSG00000117676	ENSG00000215045
Uniprot IDs		Q15418	A4D2P6 C9J5F6
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction	Cerebellar Granule Cell Differentiation Positive Regulation Of Long-term Synaptic Depression AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Complex Trans-synaptic Signaling Trans-synaptic Protein Complex Synaptic Signaling Chemical Synaptic Transmission Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Ribosomal Protein S6 Kinase Activity Synaptic Signaling Via Neuropeptide Cell-cell Signaling Excitatory Synapse Assembly Signaling Cell Communication Glutamate Receptor Activity Prepulse Inhibition Regulation Of Long-term Synaptic Depression Glutamatergic Neuron Differentiation Regulation Of Postsynaptic Density Assembly Somatodendritic Compartment Regulation Of Postsynaptic Specialization Assembly Cell Differentiation In Hindbrain Parallel Fiber To Purkinje Cell Synapse Regulation Of Excitatory Synapse Assembly Regulation Of Translation In Response To Stress Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Synapse AMPA Glutamate Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Synapse Assembly Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Excitatory Postsynaptic Potential TORC1 Signaling Scaffold Protein Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Multicellular Organismal Process PDZ Domain Binding TOR Signaling
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