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RPS6KA1 and SYK
Number of citations of the paper that reports this interaction (PubMedID
9218456
)
0
Data Source:
HPRD
(in vitro)
RPS6KA1
SYK
Description
ribosomal protein S6 kinase A1
spleen associated tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Synapse
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
B Cell Receptor Complex
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Phospholipase Binding
Scaffold Protein Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Chemical Synaptic Transmission
Positive Regulation Of Cell Growth
Negative Regulation Of TOR Signaling
Intracellular Signal Transduction
TORC1 Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Translation In Response To Stress
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Autophagosome Assembly
Angiogenesis
Cell Activation
Positive Regulation Of Cytokine Production
Serotonin Secretion
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Immune System Process
Serotonin Secretion By Platelet
Cell Surface Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Integrin-mediated Signaling Pathway
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Cellular Response To Nutrient Levels
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Mast Cell Cytokine Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-3-mediated Signaling Pathway
TORC1 Signaling
Gamma-delta T Cell Differentiation
Defense Response To Bacterium
Mast Cell Degranulation
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Positive Regulation Of MAPK Cascade
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Regulation Of Phagocytosis
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of DNA-binding Transcription Factor Activity
Establishment Of Localization In Cell
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Lipid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonate Secretion
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Amyloid-beta Clearance
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Cellular Response To Amyloid-beta
Cellular Response To Lectin
Pathways
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Transcriptional and post-translational regulation of MITF-M expression and activity
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Purvalanol A
Fostamatinib
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Entospletinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Fasting plasma glucose (
31932636
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
32888494
)
Mean corpuscular volume (
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
30108155
)
White blood cell count (
32888494
)
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Interacting Genes
88 interacting genes:
ARHGEF11
ARHGEF12
ATM
ATXN3
BAD
CARHSP1
CCT4
CDKN1B
CEBPB
CFL1
CREB1
CREBBP
DDAH2
DEPTOR
DLC1
DLG4
EEF1D
EEF2K
ERBIN
ESR1
ETV1
FGFR1
FOS
GBP2
GMFB
GOPC
GORASP1
GORASP2
GRB2
GRID2IP
GSK3B
HTRA1
L1CAM
LIMK2
LNX1
MAGI1
MAGI2
MAGI3
MAPK1
MAPK3
MAPT
MAST1
MAST2
METTL1
MITF
MPP1
MTOR
MXD1
NFKBIA
NHERF2
NR4A1
NR4A2
NR4A3
PARD3B
PDCD4
PDPK1
PDZD7
PDZK1
PDZRN3
PDZRN4
PHAX
POLDIP3
PPM1G
PPP1R3A
PPP1R9A
PTPN3
RPTOR
SHANK3
SHROOM2
SNTA1
SNTB1
SNTG2
SNX27
SRF
SRSF5
STAT3
SYK
SYNJ2BP
TAMALIN
TOB2
TP53
TSC2
TTK
UBE2T
VCP
WHRN
YBX1
YWHAB
110 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
CEBPA
COASY
CRKL
CRYAA
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TRIM31
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
Entrez ID
6195
6850
HPRD ID
03402
02514
Ensembl ID
ENSG00000117676
ENSG00000165025
Uniprot IDs
Q15418
C3W981
P43405
PDB IDs
2WNT
2Z7Q
2Z7R
2Z7S
3RNY
3TEI
4H3P
4NIF
5CSF
5CSI
5CSJ
5CSN
5N7D
5N7F
5N7G
5V61
5V62
6TWY
7P74
7PC8
7QQL
8WF4
8XOV
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
6ZC0
6ZCP
6ZCQ
6ZCR
6ZCS
6ZCU
6ZCX
6ZCY
7Q5T
7Q5U
7Q5W
7Q63
7SA7
8BI2
8RRQ
8RRZ
8WYW
8X5K
8XQ0
8XQ1
8XQ2
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Cytoplasm
Phosphatase Binding
Regulation Of Cell Development
Positive Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Cellular Component Organization
Nuclear Glucocorticoid Receptor Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Differentiation
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein-containing Complex Assembly
Cellular Response To Nutrient Levels
TOR Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of TOR Signaling
Regulation Of Multicellular Organismal Process
Cellular Response To Hormone Stimulus
Cellular Response To Peptide Hormone Stimulus
Protein Phosphorylation
Cellular Response To Stress
TORC1 Signaling
Regulation Of TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Developmental Process
Negative Regulation Of Signal Transduction
Regulation Of Osteoclast Differentiation
Response To Peptide Hormone
Regulation Of Multicellular Organismal Development
Negative Regulation Of Autophagy
Response To Decreased Oxygen Levels
Regulation Of TOR Signaling
Negative Regulation Of Catabolic Process
Intracellular Protein Localization
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Organelle Organization
Response To Oxygen Levels
Regulation Of Developmental Process
PDZ Domain Binding
Response To Nutrient Levels
Cellular Response To Cytokine Stimulus
Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Leukocyte Activation
Cell Activation
Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Lymphocyte Activation
Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Immune Response-activating Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cell Activation
Activation Of Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Immune Response
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Effector Process
B Cell Activation
Cellular Developmental Process
Adaptive Immune Response
Fc-gamma Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Population Proliferation
Intracellular Signaling Cassette
Membrane Raft
Cytokine-mediated Signaling Pathway
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Leukocyte Differentiation
Cell Differentiation
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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Tagcloud (Intersection)
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