RPS6KA1 and TOB2

Number of citations of the paper that reports this interaction (PMID 11260258)
4

Data Source:
HPRD (in vivo, in vitro)

		RPS6KA1	TOB2
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 1	transducer of ERBB2, 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Vitamin D Receptor Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Positive Regulation Of Cell Growth Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Hepatic Stellate Cell Activation	Female Gamete Generation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification
Pathways		Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		51 interactors: ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DLC1 EEF1D EEF2K ESR1 ETV1 FGFR1 FOS GBP2 GMFB GRB2 GSK3B L1CAM MAGI1 MAPK1 MAPK3 MAPT METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PDCD4 PDPK1 PHAX POLDIP3 PPM1G PPP1R3A RPTOR SRF SRSF5 SYK TOB2 TSC2 TTK VCP YBX1 YWHAB	5 interactors: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1
Entrez ID		6195	10766
HPRD ID		03402	09583
Ensembl ID		ENSG00000117676	ENSG00000183864
Uniprot IDs		E9PRI4 Q15418	Q14106
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Response To Organonitrogen Compound Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Immune Response Response To Growth Factor Regulation Of Immune Response Defense Response Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Phosphatidylinositol-mediated Signaling Response To External Stimulus Cellular Response To Hormone Stimulus Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Heat Immune System Process Cell Communication Regulation Of Phosphorylation Response To Temperature Stimulus Response To Peptide Hormone Positive Regulation Of Transcription, DNA-templated Signal Transduction Signaling Positive Regulation Of Gene Expression Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chemotaxis Cellular Response To Insulin Stimulus	Positive Regulation Of MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Translation Gene Silencing By MiRNA Posttranscriptional Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Hepatic Stellate Cell Activation MRNA Catabolic Process RNA Catabolic Process Regulation Of Gene Expression, Epigenetic Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Centriole Replication MRNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Translation In Response To Stress Aromatic Compound Catabolic Process Regulation Of MRNA 3'-end Processing Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleic Acid-templated Transcription MRNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Photoperiodism Entrainment Of Circadian Clock RNA Processing Regulation Of Protein Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cell Proliferation Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Centrosome Duplication
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition	angio bioinformatics colony downregulate dramatically erbb2 genesis indicates invasion investigations mechanistic micrornas migration mir mirnas nasopharyngeal negatively np69 npc numerous onco opposite predict promoted providing repressed transducer upregulated upregulation
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition	angio bioinformatics colony downregulate dramatically erbb2 genesis indicates invasion investigations mechanistic micrornas migration mir mirnas nasopharyngeal negatively np69 npc numerous onco opposite predict promoted providing repressed transducer upregulated upregulation
Tagcloud (Intersection) ?