ATP6V1H and PPP1R12C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V1H	PPP1R12C
Description		ATPase H+ transporting V1 subunit H	protein phosphatase 1 regulatory subunit 12C
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	Stress Fiber Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding ATP Hydrolysis Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Monoatomic Ion Transport Endocytosis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	Signal Transduction Neuron Projection Morphogenesis
Pathways		ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14	27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1
Entrez ID		51606	54776
HPRD ID		10591	11452
Ensembl ID		ENSG00000047249	ENSG00000125503
Uniprot IDs		B3KUZ7 Q9UI12	Q9BZL4
PDB IDs		6WM2 6WM3 6WM4 7FDA 7FDB 7FDC 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Response To Interleukin-1 Neural Crest Cell Fate Specification Male Germ-line Sex Determination Cellular Response To Interleukin-1 Negative Regulation Of Beta-catenin-TCF Complex Assembly Bronchus Cartilage Development Ureter Urothelium Development Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Ureter Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Intrahepatic Bile Duct Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Ubiquitin-specific Protease Activity Sulfur Dioxygenase Activity Cytoplasm Proton-transporting Two-sector ATPase Complex Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Cell-matrix Adhesion Negative Regulation Of Photoreceptor Cell Differentiation Metanephric Tubule Formation Stem Cell Fate Specification Renal Vesicle Induction Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Chondrocyte Hypertrophy Cell Proliferation Involved In Heart Morphogenesis Trachea Cartilage Development Response To Heparin Prostate Gland Morphogenesis Cellular Response To Heparin Regulation Of Branching Involved In Lung Morphogenesis Endochondral Bone Morphogenesis Anterior Head Development Primary Sex Determination Harderian Gland Development Astrocyte Fate Commitment Common Bile Duct Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Growth Plate Cartilage Chondrocyte Growth Lacrimal Gland Development Protein Linear Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Positive Regulation Of Protein Deubiquitination Hydrogen Sulfide Metabolic Process Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Ureter Development	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation
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