ATP6V1H

Gene Name		ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATPase Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Cellular Iron Ion Homeostasis Endocytosis Vacuolar Acidification Metabolic Process Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Viral Process Transferrin Transport Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity Interaction With Host Transmembrane Transport Phagosome Maturation
Pathways		Phagosomal maturation (early endosomal stage) Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Iron uptake and transport HIV Infection Nef Mediated CD8 Down-regulation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Transferrin endocytosis and recycling Insulin receptor recycling Latent infection of Homo sapiens with Mycobacterium tuberculosis Nef Mediated CD4 Down-regulation Signaling by Insulin receptor
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)
Protein-protein Interactions		4 interactors: ATP6V1E1 ETHE1 SOX9 TANK
Entrez ID		51606
HPRD ID		10591
Ensembl ID		ENSG00000047249
Uniprot IDs		B3KUZ7 B4E054 G3V126 Q9UI12
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Involved In Tissue Homeostasis Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Retinal Rod Cell Differentiation Primary Prostatic Bud Elongation Male Germ-line Sex Determination Renal Vesicle Induction Primary Sex Determination Astrocyte Fate Commitment Positive Regulation Of Extracellular Matrix Assembly Metanephric Nephron Tubule Formation Intestinal Epithelial Structure Maintenance Intrahepatic Bile Duct Development Positive Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Photoreceptor Cell Differentiation Cellular Response To Heparin Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Regulation Of Extracellular Matrix Assembly Ureter Urothelium Development Hydrogen Sulfide Metabolic Process Response To Heparin Ureter Morphogenesis Ureter Smooth Muscle Cell Differentiation Chondrocyte Hypertrophy Metanephric Tubule Formation Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Limb Bud Formation Otic Vesicle Formation Positive Regulation Of Male Gonad Development Otic Vesicle Morphogenesis Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Metanephric Tubule Morphogenesis Cellular Response To Organonitrogen Compound Camera-type Eye Photoreceptor Cell Differentiation Sulfur Amino Acid Catabolic Process Male Sex Determination Maintenance Of Gastrointestinal Epithelium Otic Vesicle Development Ureter Development ERK1 And ERK2 Cascade Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Heart Valve Formation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Metanephric Nephron Tubule Development Nephron Tubule Formation Epithelial Structure Maintenance
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