ATP6V1H and ATP6V1E1

Number of citations of the paper that reports this interaction (PMID 12163484)
13

Data Source:
HPRD (two hybrid, in vitro)

		ATP6V1H	ATP6V1E1
Gene Name		ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Vesicular Exosome	Mitochondrion Lysosomal Membrane Endosome Cytosol Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting Two-sector ATPase Complex, Catalytic Domain Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATPase Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Hydrogen-exporting ATPase Activity, Phosphorylative Mechanism Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Cellular Iron Ion Homeostasis Endocytosis Vacuolar Acidification Metabolic Process Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Viral Process Transferrin Transport Regulation Of Defense Response To Virus By Virus Regulation Of Catalytic Activity Interaction With Host Transmembrane Transport Phagosome Maturation	Cellular Iron Ion Homeostasis Metabolic Process Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Interaction With Host Transmembrane Transport Phagosome Maturation
Pathways		Phagosomal maturation (early endosomal stage) Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Iron uptake and transport HIV Infection Nef Mediated CD8 Down-regulation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Transferrin endocytosis and recycling Insulin receptor recycling Latent infection of Homo sapiens with Mycobacterium tuberculosis Nef Mediated CD4 Down-regulation Signaling by Insulin receptor	Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		4 interactors: ATP6V1E1 ETHE1 SOX9 TANK	13 interactors: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H MESDC2 SLC9A3R1 SOS1 TRAF6 XRCC6
Entrez ID		51606	529
HPRD ID		10591	00163
Ensembl ID		ENSG00000047249	ENSG00000131100
Uniprot IDs		B3KUZ7 B4E054 G3V126 Q9UI12	P36543 Q53Y06
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Involved In Tissue Homeostasis Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Retinal Rod Cell Differentiation Primary Prostatic Bud Elongation Male Germ-line Sex Determination Renal Vesicle Induction Primary Sex Determination Astrocyte Fate Commitment Positive Regulation Of Extracellular Matrix Assembly Metanephric Nephron Tubule Formation Intestinal Epithelial Structure Maintenance Intrahepatic Bile Duct Development Positive Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Photoreceptor Cell Differentiation Cellular Response To Heparin Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Regulation Of Extracellular Matrix Assembly Ureter Urothelium Development Hydrogen Sulfide Metabolic Process Response To Heparin Ureter Morphogenesis Ureter Smooth Muscle Cell Differentiation Chondrocyte Hypertrophy Metanephric Tubule Formation Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Limb Bud Formation Otic Vesicle Formation Positive Regulation Of Male Gonad Development Otic Vesicle Morphogenesis Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Metanephric Tubule Morphogenesis Cellular Response To Organonitrogen Compound Camera-type Eye Photoreceptor Cell Differentiation Sulfur Amino Acid Catabolic Process Male Sex Determination Maintenance Of Gastrointestinal Epithelium Otic Vesicle Development Ureter Development ERK1 And ERK2 Cascade Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Heart Valve Formation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Metanephric Nephron Tubule Development Nephron Tubule Formation Epithelial Structure Maintenance	Fructose 1,6-bisphosphate Metabolic Process Transferrin Transport Homeostatic Process Phagosome Maturation Transition Metal Ion Homeostasis Insulin Receptor Signaling Pathway Cellular Homeostasis Cellular Response To Insulin Stimulus Cellular Ion Homeostasis Iron Ion Transport Cellular Iron Ion Homeostasis Fructose Metabolic Process Cellular Chemical Homeostasis Interaction With Host Ion Homeostasis Response To Insulin Iron Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metal Ion Homeostasis Hydrogen Ion Transmembrane Transport Response To Organonitrogen Compound Cellular Cation Homeostasis Response To Peptide Hormone Chemical Homeostasis Metal Ion Homeostasis Cellular Response To Organonitrogen Compound Gluconeogenesis Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Proton Transport Cell Surface Receptor Signaling Pathway Hexose Biosynthetic Process Cellular Response To Hormone Stimulus Glycolytic Process Monovalent Inorganic Cation Transport Vacuolar Acidification Response To Stimulus Pyruvate Metabolic Process Intracellular PH Reduction Metal Ion Transport Carbohydrate Catabolic Process Glucose Metabolic Process PH Reduction Carbohydrate Biosynthetic Process Response To Hormone Protein Complex Assembly Response To Organic Substance Platelet Activation
Tagcloud ?			ae2 apical aqp9 aquaporin bapta bdkrb1 bdkrb2 caput cauda ciliated colocalize corpus ducts efferent epididymal epididymidis epididymis exchanger glycerol kks lcm microdissection nonciliated official pole solute stereocilia symbol uniform
Tagcloud (Difference) ?			ae2 apical aqp9 aquaporin bapta bdkrb1 bdkrb2 caput cauda ciliated colocalize corpus ducts efferent epididymal epididymidis epididymis exchanger glycerol kks lcm microdissection nonciliated official pole solute stereocilia symbol uniform
Tagcloud (Intersection) ?