HNRNPUL1 and RPA2

Number of citations of the paper that reports this interaction (PMID 18480432)
18

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HNRNPUL1	RPA2
Gene Name		heterogeneous nuclear ribonucleoprotein U-like 1	replication protein A2, 32kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ribonucleoprotein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Poly(A) RNA Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Processing RNA Splicing Response To Virus Gene Expression	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cellular Response To Heat Regulation Of DNA Damage Checkpoint
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		46 interactors: BRD7 C14orf1 CRMP1 DZIP3 EP300 ERG EWSR1 GIT2 HNRNPF HNRNPH2 HNRNPH3 IL7R ITCH MAPK1IP1L MARS MED31 NEDD4 NXF1 NXF2 NXF3 PIAS4 PPIL1 PRMT1 PRMT2 PRPF40A RBM22 RBM4 RBM4B ROPN1 RPA1 RPA2 SF1 SF3B4 SMN1 SMN2 SNRPB2 SNRPC SORBS3 SRSF9 TGM2 TLX3 TP53 TP53BP2 VPS37C WWP2 ZNF207	49 interactors: ACP5 APP ATM CALCOCO2 CCNO CDC5L CDK1 CFB COPS6 CRMP1 EEF1A1 EIF4G2 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 KIAA1377 LRIF1 MCM2 MCM3 MCM4 MCM5 MED31 MEN1 ORC1 ORC2 ORC4 ORC5 PRKDC PRPF19 RAD1 RAD52 RAD9A RBM48 RFWD3 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA
Entrez ID		11100	6118
HPRD ID		10428	01566
Ensembl ID		ENSG00000105323	ENSG00000117748
Uniprot IDs		B7Z4B8 Q9BUJ2	P15927
PDB IDs			1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Export From Nucleus Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleocytoplasmic Transport Nuclear Transport RNA Export From Nucleus Regulation Of RNA Metabolic Process Entrainment Of Circadian Clock By Photoperiod Cellular Metabolic Process Photoperiodism Entrainment Of Circadian Clock Ribonucleoprotein Complex Assembly Regulation Of Cellular Response To Heat Protein K63-linked Ubiquitination DNA Recombinase Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Viral Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cellular Metabolic Process MRNA Transport Regulation Of Cell Cycle Phase Transition Nuclear Export Spliceosomal SnRNP Assembly Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine MRNA Splice Site Selection Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition RNA Transport	DNA Metabolic Process Cell Cycle Process Cell Cycle DNA Replication Heterocycle Metabolic Process DNA Replication Initiation Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication DNA Repair G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To Stress Cell Cycle Checkpoint Response To Radiation Cellular Metabolic Process Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair Regulation Of Cell Cycle DNA Recombinase Assembly Response To Abiotic Stimulus DNA Recombination DNA Catabolic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Aromatic Compound Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction Involved In DNA Damage Checkpoint Metabolic Process
Tagcloud ?			53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide
Tagcloud (Difference) ?			53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide
Tagcloud (Intersection) ?