LARP7 and PRPF40A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		LARP7	PRPF40A
Description		La ribonucleoprotein 7, transcriptional regulator	pre-mRNA processing factor 40A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D Sno(s)RNA 3'-end Processing RNA Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		79 interacting genes: APP BARD1 BRCA1 JMJD6 LRRK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RN7SK WEE2-AS1	132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		51574	55660
HPRD ID		17095	10995
Ensembl ID		ENSG00000174720	ENSG00000196504
Uniprot IDs		A0A8I5KUI4 A0A8Q3SHH4 A0A8Q3SHN7 H0YA82 Q4G0J3	A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400
PDB IDs		4WKR 5KNW 6D12 7SLP 7SLQ	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex
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