LARP7 and MIR1-2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		LARP7	MIR1-2
Description		La ribonucleoprotein 7, transcriptional regulator	microRNA 1-2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex	RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D Sno(s)RNA 3'-end Processing RNA Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		79 interacting genes: APP BARD1 BRCA1 JMJD6 LRRK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RN7SK WEE2-AS1	78 interacting genes: ADARB1 APOBEC3B C1QBP CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FUS GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM71 UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		51574	406905
HPRD ID		17095
Ensembl ID		ENSG00000174720	ENSG00000284453
Uniprot IDs		A0A8I5KUI4 A0A8Q3SHH4 A0A8Q3SHN7 H0YA82 Q4G0J3
PDB IDs		4WKR 5KNW 6D12 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Nucleus Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process P-body Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Nucleolus MRNA Stabilization Regulation Of Metabolic Process Positive Regulation Of Gene Expression TRNA Metabolic Process Negative Regulation Of Metabolic Process
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