UFM1 and UBE2D4

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UFM1	UBE2D4
Gene Name		ubiquitin-fold modifier 1	ubiquitin-conjugating enzyme E2D 4 (putative)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Protein Ufmylation Protein Polyufmylation	Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARHGDIA ARHGDIB DIABLO GSK3B RPS6KA6 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W UFC1	90 interactors: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 LRSAM1 MAGEA11 MAP3K1 MARCH3 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF26 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBE4A UBOX5 UBTD1 UFM1 UHRF2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		51569	51619
HPRD ID		15644	14242
Ensembl ID		ENSG00000120686	ENSG00000078967
Uniprot IDs		P61960	Q9Y2X8
PDB IDs		1WXS
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein Ubiquitination Cellular Response To Stress Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Protein Polyufmylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Ufmylation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Response To Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Viral Entry Into Host Cell Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Metabolic Process Negative Regulation Of Viral Process Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Viral Transcription Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Regulation Of Signal Transduction Innate Immune Response Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Interferon-gamma Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Interferon-gamma Programmed Cell Death Cell Death Death Histone Monoubiquitination
Tagcloud ?		17beta abrogated activating asc1 bound coactivator displaced e1 e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation uba5 ufmylation ufsp2	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Difference) ?		17beta abrogated activating asc1 bound coactivator displaced e1 e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation uba5 ufmylation ufsp2	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Intersection) ?